Hepatic Insulin Resistance and Whole-Body Outcomes
A special issue of Livers (ISSN 2673-4389).
Deadline for manuscript submissions: closed (25 October 2021) | Viewed by 609
Special Issue Editors
Interests: heme oxygenase; bilirubin; oxidative stress; nuclear receptors; fatty liver; glucocorticoid receptor; PPARs
Special Issues, Collections and Topics in MDPI journals
2. Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701-2979, USA
Interests: diabetes; hypertension; insulin resistance; metabolism; metabolic diseases; physiology
Special Issues, Collections and Topics in MDPI journals
Interests: liver development and disease; gene regulation; transcriptional regulation; liver cancer
Interests: obesity; diabetes; hypertension; cardiovascular disease; heme oxygenase; bilirubin; biliverdin reductase; antioxidants
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Non-alcoholic fatty liver disease (NAFLD) has risen worldwide in parallel to the rise in obesity and metabolic syndrome. Metabolic syndrome is marked by insulin resistance and is manifested in part by altered insulin and lipid metabolism. The liver is a major site of insulin clearance that, together with insulin secretion, determines the systemic insulin level that regulates insulin’s action in peripheral tissues. Dysregulation of this process leads to hepatic and systemic insulin resistance, type 2 diabetes, and its cardiovascular complications.
This Special Issue focuses on the central role that the liver plays in regulating insulin and fat metabolism, and how this may interact with adipocytes to regulate whole-body insulin sensitivity and cardiovascular functions.
Dr. Terry D. Hinds
Prof. Dr. Sonia Michael Najjar
Dr. Brett Spear
Dr. David E. Stec
Guest Editors
Manuscript Submission Information
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Keywords
- Insulin resistance
- Insulin clearance
- Hyperinsulinemia
- Non-alcoholic fatty liver disease
- Non-alcoholic steatohepatitis
- Intraabdominal adiposity
- Atherosclerosis
- Hypertension
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