Inflammatory Skin Conditions
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 October 2016) | Viewed by 397818
Special Issue Editor
Interests: inflammation; chronic wounds; rheumatoid arthritis; skin; activated protein C; matrix metalloproteinases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The skin, the body’s largest organ, provides a barrier to protect the body from environmental insults including pathogens, maintaining temperature and control evaporation. This barrier is located in the outer layer of the skin known as the epidermis, which sits on the dermis. The epidermis is composed mainly of proliferating keratinocytes in the basal layer which differentiate as they migrate outwards to become lipid-bearing corneocytes. Breaches of this barrier are common events, however, the inability to restore this barrier function can result in health problems such as inflammatory skin conditions which are very common and have high morbidity. This group of diseases includes (in approximate increasing order of severity) : acne, which affects 50% of teenagers; rosacea which affects 10% of adults; atopic dermatitis which affects up to 20% population; psoriasis which affects 2%–3% population; chronic wounds which affect <1% population and the devastating, often fatal, toxic epidermal necrolysis, which is rare. New and innovative drugs that dampen inflammation and restore the defective barrier are required to alleviate these recalcitrant conditions.
This Special Issue calls for original research, mini and full reviews, and perspectives that address the progress and current knowledge in the overlapping research topics of inflammatory skin conditions. These include, but are not limited to the fields that are mentioned in the keywords.
Chris Jackson
Guest Editor
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Keywords
- inflammatory skin conditions
- chronic wounds
- psoriasis
- dermatitis
- epidermis
- keratinocytes
- barrier function
- inflammatory cells
- immunity
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