Molecularly Targeted Therapy and Regulation of Signaling Pathway in Oral Squamous Cell Carcinoma
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 1321
Special Issue Editor
Interests: oral pathology; oral medicine; oral surgery; oral potentially malignant disorders; head and neck cancer; oral squamous cell carcioma; tumor stroma; odontogenic tumor
Special Issue Information
Dear Colleagues,
Oral squamous cell carcinoma (OSCC) is the most common malignancy of all oral cavity cancers, with over 389,846 cases diagnosed worldwide. The National Cancer Institute estimated about 58,450 new cases and 12,230 new deaths in 2024, with a short-term survival rate (2014–2020) equal to 69.0%, ranging from 87.5%, for localized tumors, to 37.8 %, for advanced cancers. Different omics sciences, such as proteomics, genomics, metabolomics, and transcriptomics, have been extensively established. Therefore, novel therapeutic strategies, target-specific drugs, and non-invasive, highly specific biomarkers could improve the survival of OSCC patients.
This Special Issue aims to highlight the most recent scientific advances, improving the diagnostics and the treatment strategies available for OSCC. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Molecular mutations and regulation of signaling pathway involved in OSCC, such as programmed cell death and epidermal growth factor receptors, vascular endothelial growth factor, cyclin-dependent kinase, mammalian targets of rapamycin inhibitors, and others;
- Targeted therapies and drug resistance involved in OSCC;
- New therapeutic approaches and drug delivery, such as the role of mutation analysis and next-generation sequencing in OSCC diagnosis and treatment.
We look forward to receiving your contributions.
Dr. Lucrezia Togni
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- head and neck cancers
- oral squamous cell carcinoma
- targeted therapies
- omics sciences
- signaling pathway
- mutations
- prognosis
- diagnostic markers
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
