Molecularly Targeted Therapy and Regulation of Signaling Pathway in Oral Squamous Cell Carcinoma
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 1101
Special Issue Editor
Interests: oral pathology; oral medicine; oral surgery; oral potentially malignant disorders; head and neck cancer; oral squamous cell carcioma; tumor stroma; odontogenic tumor
Special Issue Information
Dear Colleagues,
Oral squamous cell carcinoma (OSCC) is the most common malignancy of all oral cavity cancers, with over 389,846 cases diagnosed worldwide. The National Cancer Institute estimated about 58,450 new cases and 12,230 new deaths in 2024, with a short-term survival rate (2014–2020) equal to 69.0%, ranging from 87.5%, for localized tumors, to 37.8 %, for advanced cancers. Different omics sciences, such as proteomics, genomics, metabolomics, and transcriptomics, have been extensively established. Therefore, novel therapeutic strategies, target-specific drugs, and non-invasive, highly specific biomarkers could improve the survival of OSCC patients.
This Special Issue aims to highlight the most recent scientific advances, improving the diagnostics and the treatment strategies available for OSCC. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Molecular mutations and regulation of signaling pathway involved in OSCC, such as programmed cell death and epidermal growth factor receptors, vascular endothelial growth factor, cyclin-dependent kinase, mammalian targets of rapamycin inhibitors, and others;
- Targeted therapies and drug resistance involved in OSCC;
- New therapeutic approaches and drug delivery, such as the role of mutation analysis and next-generation sequencing in OSCC diagnosis and treatment.
We look forward to receiving your contributions.
Dr. Lucrezia Togni
Guest Editor
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Keywords
- head and neck cancers
- oral squamous cell carcinoma
- targeted therapies
- omics sciences
- signaling pathway
- mutations
- prognosis
- diagnostic markers
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