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Diet and Metabolism: Molecular Mechanisms of Health and Disease 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1283

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Guest Editor
Istituto per l’Endocrinologia e l’Oncologia Sperimentale “G. Salvatore” (IEOS), CNR, 80131 Naples, Italy
Interests: stem cells; cancer stem cells; carcinogenesis; glioblastoma; high mobility group proteins; asymmetric division; diet; adipose tissue; obesity; differentiation
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Special Issue Information

Dear Colleagues,

Nutrients are, by definition, the building blocks for energy generation and tissue homeostasis. The plethora of coordinated pathways that define their molecular fate altogether constitute our metabolism. In the last decades, metabolic alterations, caused by poor eating habits or congenital mutations, have emerged to dramatically affect human health and to foster the onset of diseases such as cardiovascular disease, diabetes, and cancer.

This Special issue calls for original articles, reviews, and perspectives addressing, but not limited to, the following:

  • the beneficial and detrimental impact of diet on human health
  • nutrients’ effect on stem cells, including cancer stem cells
  • the importance of diet in cancer prevention and response to therapies
  • the molecular mechanisms underlying tumor cellular metabolism
  • the molecular effects of caloric restriction and obesity
  • the role of diet and metabolism in immunity and autoimmune diseases
  • the action of dietary bioactive compounds
  • the crosstalk between the metabolism and microbiome
  • metabolism and cardiovascular disease, insulin resistance, and diabetes

Dr. Sabrina Battista
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • diet
  • metabolism
  • nutrients
  • stem cell
  • cancer stem cell
  • cancer metabolism
  • bioactive compounds
  • glucose
  • lipids
  • obesity
  • caloric restriction
  • high fat diet
  • cardiovascular disease
  • diabetes
  • oxygen
  • hypoxia
  • immune system
  • microbiota
  • autoimmune disease
  • insulin resistance
  • nutraceutics
  • cancer prevention
  • tumor cell metabolism
  • biosynthesis
  • energy
  • glycolysis
  • carbohydrates
  • amino acids
  • homeostasis
  • sirtuins
  • mTOR
  • exercise

Published Papers (1 paper)

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Research

13 pages, 1788 KiB  
Article
Differential Modulation of Mouse Intestinal Organoids with Fecal Luminal Factors from Obese, Allergic, Asthmatic Children
by Samir Córdova, Mireia Tena-Garitaonaindia, Ana Isabel Álvarez-Mercado, Reyes Gámez-Belmonte, Mª Amelia Gómez-Llorente, Fermín Sánchez de Medina, Ana Martínez-Cañavate, Olga Martínez-Augustin and Carolina Gómez-Llorente
Int. J. Mol. Sci. 2024, 25(2), 866; https://doi.org/10.3390/ijms25020866 - 10 Jan 2024
Viewed by 936
Abstract
Asthma is a multifactorial condition that can be associated with obesity. The phenotypes of asthma in lean and obese patients are different, with proinflammatory signatures being further elevated in the latter. Both obesity and asthma are associated with alterations in intestinal barrier function [...] Read more.
Asthma is a multifactorial condition that can be associated with obesity. The phenotypes of asthma in lean and obese patients are different, with proinflammatory signatures being further elevated in the latter. Both obesity and asthma are associated with alterations in intestinal barrier function and immunity, and with the composition of the intestinal microbiota and food consumption. In this study, we aimed to establish an organoid model to test the hypothesis that the intestinal content of lean and obese, allergic, asthmatic children differentially regulates epithelial intestinal gene expression. A model of mouse jejunum intestinal organoids was used. A group of healthy, normal-weight children was used as a control. The intestinal content of asthmatic obese children differentially induced the expression of inflammatory and mitochondrial response genes (Tnf-tumor necrosis factor, Cd14, Muc13-mucin 13, Tff2-Trefoil factor 2 and Tff3, Cldn1-claudin 1 and 5, Reg3g-regenerating family member 3 gamma, mt-Nd1-NADH dehydrogenase 1 and 6, and mt-Cyb-mitochondrial cytochrome b) via the RAGE-advanced glycosylation end product-specific receptor, NF-κB-nuclear factor kappa b and AKT kinase signal transduction pathways. Fecal homogenates from asthmatic normal-weight and obese children induce a differential phenotype in intestinal organoids, in which the presence of obesity plays a major role. Full article
(This article belongs to the Special Issue Diet and Metabolism: Molecular Mechanisms of Health and Disease 2.0)
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