Gut Microbiota and Immunity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 58936
Special Issue Editor
Interests: effects of ethanol on TLR4 immune response; extracellular vesicles; effect of binge drinking in adolescent brain; microbiome; inflammatory response; glial cells
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Special Issue Information
The human gut hosts a wide and diverse ecosystem of microorganisms termed the microbiota or the novel name “holobiota”. The microbiota is involved in both health and disease, contributing to prevent illness by facilitating the metabolism, the immune system, cancer resistance, endocrine signaling and brain function. However, dysfunctions of the microbiota could lead to gut dysbiosis, leading to alterations of the intestinal permeability and in the immune system. Innate and adaptive immunity plays an important role in the containment and clearance of microbial pathogens, and new mechanisms have been discovered that can cause or influence systemic immunity alterations in different disorders, such as cancer, autoimmune or neurodegenerative diseases, among others. In this Special Issue, a particular emphasis will be given to the role of the microbiota–gut–brain axis, to deepen the knowledge of the mechanisms of gut microbiota–brain communication, including immune signaling and neural–enteroendocrine pathways. We will also review important advances in techniques associated with microbial research, such as DNA sequencing, metabolomics, and proteomics combined with computation-based bioinformatics. Finally, this Special Issue of IJMS will also focus on advances in therapeutic applications, for instance, the usefulness of microbial or chemobiotic applications as promising therapeutic choices to palliate immune-mediated diseases, neurodegenerative disorders, and other syndromes.
Dr. Maria Pascual
Guest Editor
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Keywords
- gut
- microbiota
- immune response
- infectious disease
- cancer
- brain function
- metabolism
- endocrine signaling
- pathological conditions
- therapy
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