Special Issue "The Role of Glycosylation in Host-Microbial Interactions"
Deadline for manuscript submissions: 31 August 2020.
Interests: Glycosciences; Diagnostics; biomarkers; therapeutics; molecular biomimics
Interests: host-microbe interactions; immune response; bacterial polysaccharides and biofilms; and the application and development of carbohydrate analytical methods and platforms for analytics
Carbohydrates are ubiquitously present on all living cell surfaces and as major extracellular matrix components that play critical biological roles in human health and disease. Although many aspects of the field of glycoscience encompassing structural complexity and functional relevance are still not well understood, significant advances have been made since the turn of the century elucidating the central roles played by carbohydrate–protein interactions.
One major field of advance in glycoscience and its role in biology is in the domain of host–microbial interactions. Most microbial interactions with host surfaces are mediated by carbohydrate–protein interactions to establish pathogenic or commensal relationships. In addition to the roles identified in host–pathogen interactions, our understanding of the role of gastrointestinal tract mucosal surface in colonisation of the host gut by commensal microbiome is in its infancy. Mucins are the main components of host mucus, and mucin glycosylation functions as ligands for bacterial adhesins and as a source of microbial nutrients. Mucin glycosylation is very responsive to the immediate environment and varies depending on species, location in the body, hormonal status, inflammation, and presence of microbes. In addition, microbes can interact with the host via their surface glycosylation, and this may provide vaccine targets, e.g., bacterial capsular polysaccharides have been used as vaccines such as pneumococcal vaccines. Many factors, including diet, influence gut glycosylation and the microbial population and thus have an impact on their interactions and cross-talk, thus effecting human gut health and disease.
This Issue will elucidate the role of microbial or host glycosylation in host–microbe interactions in human health and disease.
Prof. Dr. Lokesh Joshi
Dr. Michelle Kilcoyne
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- gastrointestinal tract
- host–microbe interactions