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Genomic Research in Neurobiology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 1966

Special Issue Editors


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Guest Editor
Institute of Cellular and Developmental Biology, Division of Neuroscience, Biomedical Sciences Research Centre Alexander Fleming, 16672 Vari, Attika, Greece
Interests: mechanisms of associative and nonassciative learning and memory; Drosophila and mouse models of intelectual disability; neurological and psychiatric conditions
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Institute for Fundamental Biomedical Research, Biomedical Sciences Research Centre "Alexander Fleming", 34 Fleming Street, 16672 Vari, Greece
Interests: tao protein; drosophila model; proteomic

Special Issue Information

Dear Colleagues,

Advances in -omics and sequencing technologies, even at the single-neuron level, enable the extraordinary multilevel profiling of neuronal physiology, responses to acute insults, pharmacological treatments, and pathological settings. In addition, genome-wide association studies have provided unprecedented insights into complex psychiatric conditions, such as schizophrenia and autism, among others, but also neurodegenerative diseases of the central and peripheral nervous systems.

As further advances are expected to yield even more and likely increasingly refined information on potential disease-linked polymorphisms and the global transcriptional, post-transcriptional, translational, and signaling responses of neurons, methods and experimental systems as well as models are needed to validate and expand these findings. This Special Issue of “Genomic Research in Neurobiology” will focus on, but will not be limited to, novel -omics technological developments and findings, their computational treatment, and novel model systems for their biological validation. In addition, we aim to host novel validated -omics approaches that enhance our understanding of hallmark physiological functions of the nervous system, such as the multiple types of learning and memory that characterize it.

This Special Issue is supervised by Prof. Dr. Efthimios M. C. Skoulakis, Dr. Katerina Papanikolopoulou and assisted by our Topical Advisory Panel Member Dr. Chih-Wei Zeng (University of Texas Southwestern Medical Center).

Prof. Dr. Efthimios M. C. Skoulakis
Dr. Katerina Papanikolopoulou
Guest Editors

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Keywords

  • neuro-omics
  • GWAS
  • single-neuron approaches
  • neurodegenerative -omics
  • psychiatric -omics
  • omics validation models and systems

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Published Papers (1 paper)

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Research

17 pages, 3042 KiB  
Article
1-L Transcription in Prion Diseases
by Jozef Nahalka
Int. J. Mol. Sci. 2024, 25(18), 9961; https://doi.org/10.3390/ijms25189961 - 15 Sep 2024
Viewed by 1333
Abstract
Understanding the pathogenesis and mechanisms of prion diseases can significantly expand our knowledge in the field of neurodegenerative diseases. Prion biology is increasingly recognized as being relevant to the pathophysiology of Alzheimer’s disease and Parkinson’s disease, both of which affect millions of people [...] Read more.
Understanding the pathogenesis and mechanisms of prion diseases can significantly expand our knowledge in the field of neurodegenerative diseases. Prion biology is increasingly recognized as being relevant to the pathophysiology of Alzheimer’s disease and Parkinson’s disease, both of which affect millions of people each year. This bioinformatics study used a theoretical protein-RNA recognition code (1-L transcription) to reveal the post-transcriptional regulation of the prion protein (PrPC). The principle for this method is directly elucidated on PrPC, in which an octa-repeat can be 1-L transcribed into a GGA triplet repeat RNA aptamer known to reduce the misfolding of normal PrPC into abnormal PrPSc. The identified genes/proteins are associated with mitochondria, cancer, COVID-19 and ER-stress, and approximately half are directly or indirectly associated with prion diseases. For example, the octa-repeat supports CD44, and regions of the brain with astrocytic prion accumulation also display high levels of CD44. Full article
(This article belongs to the Special Issue Genomic Research in Neurobiology)
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