Molecular Advances in Alzheimer’s Disease 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 1992
Special Issue Editor
Interests: Alzheimer’s disease; Parkinson’s disease; biomarkers; protein’s deposition; neuroinflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alzheimer’s disease (AD), the most common cause of dementia among the elderly, is characterized by loss of memory and other cognitive functions. The main neuropathological changes associated with AD include synaptic and neuronal loss, astrogliosis, and protein deposition. Despite these neuropathological hallmarks, emerging data suggest that the disease has a complex aetiology; neuroinflammation, oxidative stress, and mitochondrial dysfunction seem to play an important role in the pathophysiology of mild cognitive impairment and AD, as well as in other neurodegenerative disorders such as Parkinson’s disease. However, the underlying molecular mechanisms associated with these alterations are still elusive. Unfortunately, AD diagnosis occurs at a stage in which the underlying pathology has reached an advanced and possibly irreversible state. Therefore, the major challenges in AD research are to identify biomarkers for early diagnosis and finding therapeutic strategies that prevent the development of the pathology. For that, we need to decipher the cellular and molecular mechanisms that underlie AD and other neurodegenerative diseases, as well as their progression and severity.
This Special Issue will focus on reviews and original data manuscripts that concern (1) the molecular mechanism of Alzheimer’s and other neurodegenerative diseases; (2) molecular targets for new Alzheimer’s biomarkers; (3) the genetics of Alzheimer’s and other neurogenerative diseases; (4) molecular targets for new therapeutic techniques for Alzheimer’s; (5) the molecular mechanism of neuroinflammation in neurodegenerative diseases.
Dr. María-Salud García-Ayllón
Guest Editor
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Keywords
- molecular targets
- neurodegenerative diseases
- Alzheimer’s disease
- Parkinson’s
- neuroinflammation
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