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Special Issue "G Protein-Coupled Adenosine Receptors: Molecular Aspects and Beyond"
Deadline for manuscript submissions: 1 March 2020.
Interests: G protein-coupled receptors; adenosine receptors; neuropharmacology; neurological diseases; allosteric modulation; receptor-receptor interactions; psychiatric diseases
Special Issues and Collections in MDPI journals
Adenosine is a well-known neuromodulator in the brain, and has effects on other tissues like immune or circulatory systems. Its physiological actions are exerted mainly through four different subtypes of G protein-coupled adenosine receptors (i.e., A1R, A2AR, A2BR, and A3R), which are expressed in a large variety of cells throughout the body. Thus, ARs are potential therapeutic targets in a variety of pathophysiological conditions, including cancer, cardiovascular diseases, neurological disorders, and inflammatory and autoimmune diseases.
Consequently, interest in the molecular structure and pharmacology of ARs has increased in recent years. Interestingly, more than 30 crystal structures for human ARs have been reported in the last decade, thus making it the most structurally characterized GPCR. In addition, selective agonists and antagonists for all four AR subtypes have been developed, and its diagnostic and therapeutic utility is being pursued.
Using ARs as a paradigm of purinergic GPCRs, the following Special Issue intends to provide the reader with a flavor of the structural and pharmacological recent developments of ARs. Thus, the submissions of papers describing new molecular, physiological, and pharmacological aspects of ARs are welcome. In addition, manuscripts describing new AR-based chemical tools or approaches for the study of the adenosine function, prospective analysis for the therapeutic future of ARs ligands, and reviews will be also taken into consideration. Finally, authors are encouraged to propose topics that will be evaluated accordingly. Overall, we hope that this timely focused Issue summarizing our current knowledge on adenosine receptors will be of interest to a wide range of readers of the journal.
Prof. Dr. Francisco Ciruela
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- molecular mechanism
- adenosine receptor ligands
- G protein-coupled receptors
- signal transduction
- receptor–receptor interactions
- medicinal chemistry
- purinergic pharmacology.
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: The impact of genetic variations in ADORA2A in the association between caffeine consumption and sleep
Authors: Erblang Megane, ... and Chennaoui Mounir
1.Département Environnements Opérationnels, Unité Fatigue et Vigilance, Institut de recherche biomédicale des armées (IRBA), Brétigny sur Orge, France
2. EA 7330 VIFASOM, H?tel Dieu, Université Paris Descartes, Paris, France
Title: Accuracy and precision of the receptorial responsiveness method (RRM) in the quantification of A1 adenosine receptor agonists
Authors: Rudolf Gesztelyi, etc.