ijms-logo

Journal Browser

Journal Browser

Fetal Nutrition and Neuro-Development

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 5095

Special Issue Editor


E-Mail
Guest Editor
UMR 1280 PHAN, INRAE (National Research Institute for Agriculture, Food and Environment), Nantes, France
Interests: early nutrition; fetal development; neuro-development; epigenetics; neural stem cells; cell differentiation

Special Issue Information

Dear Colleagues,

In mammals, all the nutrients needed by the fetus are provided by the mother under a strict regulation by the placenta that plays the double role as nutrient provider and endocrine organ.

Neurodevelopment during embryo and fetal development relies on a precise control of proliferation, differentiation and migration of the several types of neural cells that constitute the different brain areas. These processes are determined by internal programs but they are also responsive to external cues, among which nutrient availability. Cellular differentiation of neural stem/progenitor cells relies on the expression of lineage specific genes. This process is strictly regulated at the pre- and post-transcriptional level but the influence of environmental cues, especially nutrients, on these regulatory systems is still very poorly characterized.

The purpose of this special issue is to investigate the impact of maternal nutrition or metabolic status (including obesity and special diets such as vegetarian or vegan) on fetal neurodevelopment. Emphasis will be placed on the cellular and molecular mechanisms, including cellular energy metabolism, epigenetics or epitranscriptomics, by which nutrients reaching the fetus may influence key neurodevelopmental milestones and affect brain function.

Experimental studies in in vitro and in vivo models, review articles are all welcome for consideration.

Dr. Valerie Amarger
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Maternal nutrition
  • Neuro-development
  • Neurogenesis
  • Neural stem/progenitor cells
  • Cell differentiation
  • Epigenetics
  • Epitranscriptomics

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

24 pages, 25810 KiB  
Article
Epigallocatechin Gallate Ameliorates the Effects of Prenatal Alcohol Exposure in a Fetal Alcohol Spectrum Disorder-Like Mouse Model
by Laura Almeida-Toledano, Vicente Andreu-Fernández, Rosa Aras-López, Óscar García-Algar, Leopoldo Martínez and María Dolores Gómez-Roig
Int. J. Mol. Sci. 2021, 22(2), 715; https://doi.org/10.3390/ijms22020715 - 13 Jan 2021
Cited by 22 | Viewed by 4708
Abstract
Fetal alcohol spectrum disorder is the main preventable cause of intellectual disability in the Western world. Although binge drinking is the most studied prenatal alcohol exposure pattern, other types of exposure, such as the Mediterranean, are common in specific geographic areas. In this [...] Read more.
Fetal alcohol spectrum disorder is the main preventable cause of intellectual disability in the Western world. Although binge drinking is the most studied prenatal alcohol exposure pattern, other types of exposure, such as the Mediterranean, are common in specific geographic areas. In this study, we analyze the effects of prenatal alcohol exposure in binge and Mediterranean human drinking patterns on placenta and brain development in C57BL/6J mice. We also assess the impact of prenatal treatment with the epigallocatechin-3-gallate antioxidant in both groups. Study experimental groups for Mediterranean or binge patterns: (1) control; (2) ethanol; (3) ethanol + epigallocatechin-3-gallate. Brain and placental tissue were collected on gestational Day 19. The molecular pathways studied were fetal and placental growth, placental angiogenesis (VEGF-A, PLGF, VEGF-R), oxidative stress (Nrf2), and neurodevelopmental processes including maturation (NeuN, DCX), differentiation (GFAP) and neural plasticity (BDNF). Prenatal alcohol exposure resulted in fetal growth restriction and produced imbalances of placental angiogenic factors. Moreover, prenatal alcohol exposure increased oxidative stress and caused significant alterations in neuronal maturation and astrocyte differentiation. Epigallocatechin-3-gallate therapy ameliorated fetal growth restriction, attenuated alcohol-induced changes in placental angiogenic factors, and partially rescued neuronal nuclear antigen (NeuN), (doublecortin) DCX, and (glial fibrillary acidic protein) GFAP levels. Any alcohol consumption (Mediterranean or binge) during pregnancy may generate a fetal alcohol spectrum disorder phenotype and the consequences may be partially attenuated by a prenatal treatment with epigallocatechin-3-gallate. Full article
(This article belongs to the Special Issue Fetal Nutrition and Neuro-Development)
Show Figures

Figure 1

Back to TopTop