Special Issue "Pain and Inflammation"
Deadline for manuscript submissions: closed (31 December 2017) | Viewed by 23585
Interests: nerve injury and neuropathic pain; pain and aging; central adaptations to chronic pain; multiple sclerosis; neuroinflammation; neuro-immunologic communication; redox signaling; nitric oxide; endocannabinoids and other lipid signaling molecules; progranulin; autophagy
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A growing number of molecules have been suggested to contribute to the development of chronic inflammation and pain, and some of them bear some potential as drug targets based on rodent models. However, the mechanisms are not fully understood, and, traditionally, therapeutic approaches have mainly sought to antagonize the pro-inflammatory players of inflammation, with mixed success. More recently, molecular mechanisms that initiate the resolution of inflammation have opened a new avenue in pro-resolution strategies to treat complex chronic inflammatory diseases. However, resolution pathways are heterogeneous and probably tissue- and stimulus-specific. A better understanding of the balance between pro-inflammation and pro-resolution strategies addressing for example cell-to-cell receptor binding and bioactive lipid mediators are needed to develop novel therapeutic strategies.
In this Special Issue we invite original research and reviews in the field of pain and inflammation, particularly addressing molecular mechanisms of inflammation persistence versus resolution.
Prof. Dr. Irmgard Tegeder
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- resolution of inflammation
- bioactive lipids
- immune cells
- redox signaling
- macrophage polarization