Extracellular Vesicles and Cancer
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 7474
2. Research Group "Magdeburger Arbeitsgemeinschaft für Forschung unter Raumfahrt- und Schwerelosigkeitsbedingungen" (MARS), Otto von Guericke University, 39106 Magdeburg, Germany
Interests: extracellular vesicles; exosomes; small EVs; tumor microenvironment; cell-cell crosstalk; immune escape; cancer research; tumor education; immune system; real and simulated microgravity; microgravity-related health problems
Despite the many advances in research and medical care, to date cancer is still a scourge of humanity. According to the Agency for Research on Cancer an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths occurred in 2020 worldwide. The disease’s heterogeneity in regard to the causes, development, progression, and immune escape are reasons for the need of wide-ranging approaches in research.
Extracellular vesicles (EVs) have become a fast-growing focal point in biomedical research over the last decade, as they show high potential as biomarkers and in clinical applications due to their emerging roles in disease as well as normal physiology. This family of membrane vesicles are secreted into the extracellular environment by the majority of (if not all) cells and functionally mediate cell-cell communication. Numerous studies on the role of EVs in the tumour environment have shown their involvement in the modulation of immune and therapy response, the promote matrix remodelling as well as angiogenesis. Furthermore, EVs regulate tumorigenesis by increasing tumour cell proliferation, resistance to chemotherapy, and migration. Their importance as biomarkers in clinical diagnosis, and their promise to a variety of future therapeutic approaches for a wide array of diseases even aside from cancer is apparent.
Dr. Petra Wise
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- extracellular vesicles
- cell microenvironment
- cell-cell crosstalk
- cancer research
- immune escape
- microgravity research
- translational regenerative medicine