Special Issue "Metals and Cancer"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 October 2023 | Viewed by 1583
Special Issue Editors
Interests: X-ray synchrotron-based techniques; biomineralization; osteoblastic differentiation; 3D cell culture; cellular imaging
Special Issues, Collections and Topics in MDPI journals
Interests: cancer; magnesium; MDR; cell cycle; bone; differentiation
Special Issues, Collections and Topics in MDPI journals
Interests: X-ray microscopy; X-ray fluorescence; ptychography and related applications in life sciences; environmental science and cultural heritage
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metals are fundamental cellular elements for a number of biological processes, including the fundamental metabolic pathways such as energy transduction and cell proliferation. Several metals, such as Ca2+, K+, Na+, Mg2+, Zn2+, and Fe2+/Fe3+, are essential for mitochondrial function and cellular metabolism, including oxidative phosphorylation, mitochondrial integrity, proliferative signal transduction, and apoptosis. As a consequence, alterations in metal levels and/or changes in the expression of proteins involved in metal metabolism have been documented in different pathologies and several types of cancers.
Moreover, considering the key role of metals for cell growth, the development of drugs capable of metal sequestration has become an attractive target for the development of novel anti-cancer agents.
Furthermore, a large body of preclinical and clinical studies on dietary deficiencies indicates that metal dis-regulation triggers neoplastic cell transformation and/or reduces the anti-tumor functions of immune cells by controlling a plethora of chemical and biological reactions.
This Special Issue aims to encourage innovation and research activities in this field.
We invite researchers to contribute original research and review articles regarding the involvement of metal level and metabolism in cancer occurrence, progression, and prognosis.
Dr. Emil Malucelli
Dr. Concettina Cappadone
Dr. Alessandra Gianoncelli
Guest Editors
Manuscript Submission Information
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Keywords
- cancer
- metal
- cell metabolism
- mitochondria
- cell proliferation