Molecular Research in Skeletal Muscle Metabolism

Dear Colleagues,

Skeletal muscles (SKMs) are mostly used for locomotion and other physical duties, as well as preserving the structural integrity of the body and facilitating the body’s systemic blood and nutritional flow. Skeletal muscle properties and volume are inextricably linked to human health, lifespan and the quality of life. While muscle metabolism can readily satisfy the resting muscle tone, which is constant throughout the day, intense physical activities may force muscle metabolism to meet energy demands that are nearly 100 times higher than the resting values. Carefully coordinating anatomical, physiological and biochemical adaptations in response to cellular molecular reactions to repeated stressors is the only way to accomplish this enormous effort. In summary, a collection of signaling mechanisms mimics the volume, strength and resilience of muscles by first obtaining more dormant DNA material from satellite cells, then replicating particular DNA genetic sequences to facilitate the translation of subsequent genetic messages, and finally producing a sequence of amino acids that build new proteins in muscles.

The present call is intended to stimulate thoughts about recent findings or improvements in previously discovered molecular mechanisms underpinning muscle metabolism.

Dr. Dumitru Constantin-Teodosiu
Guest Editor

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• skeletal muscles
• muscle metabolism
• cellular molecular
• satellite cells