Special Issue "Modeling Human Biological Pathways in Health, Aging and Disease: The Drosophila Paradigm - in Memory of Professor Suzanne Eaton (1959-2019)"
Deadline for manuscript submissions: closed (31 October 2021).
Interests: development; Drosophila model of human diseases; oogenesis; metabolic disorders; neurological disorders; programmed cell death; proteasome
Interests: development; cancer; chemotherapy; metastasis; programmed cell death; metabolism; Drosophila aging; brain signaling
Special Issues, Collections and Topics in MDPI journals
Drosophila melanogaster, with its powerful transgenic technology that enables scientists to drive or silence the expression of a gene in a spatial and/or temporal manner, is now established as one of the most sophisticated model organisms for the in vivo investigation of mechanisms regulating, among others, cell differentiation, gene regulation, and aging.
Furthermore, the high level of structural and functional conservation in many fundamental biological processes between humans and flies, and the fact that approximately 75% of all known human disease genes have functional fly homologues, render Drosophila an ideal model for understanding the molecular mechanisms of human diseases, including malignancies. Hence, Drosophila has been effectively used for drug screenings and target discoveries, as well as for the study of various pathological conditions, such as metabolic disorders, neurodegenerative diseases, cardiovascular diseases, aging, and cancer.
Recent research in Drosophila gives special emphasis to the large-scale screening of candidate genes identified from patient genomic sequencing studies aiming at the identification of novel druggable targets for personalized medicine schemes.
For this Special Issue, we welcome original research articles and reviews by experts in this field, whose contribution will provide novel insights into the outlined research areas.
Dr. Athanassios D. Velentzas
Dr. Dimitrios J. Stravopodis
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Drosophila melanogaster
- Human disease model
- Neurodegenerative diseases
- Metabolic disorders
- Cardiovascular diseases
- Inflammatory disorders
- Cancer model
- Epigenetic dysregulation
- Stem cell maintenance
- Programmed cell death
- Cell differentiation
- Gene regulation