Special Issue "Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function"
Deadline for manuscript submissions: closed (31 March 2019).
A printed edition of this Special Issue is available here.
Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the capability to dephosphorylate Ser/Thr and Tyr residues from proteins as well as from other non-proteinaceous substrates, including signaling lipids. DUSPs include, among others, the MAP kinase (MAPK) phosphatases (MKPs) and the small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the functions of small-size atypical DUSPs seem to be more diversified. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress responses and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implied in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have important consequences in human disease, making these enzymes potential biological markers and therapeutic targets.
This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease. We encourage authors to submit original papers and reviews on this expanding and exciting research area.
Dr. Rafael Pulido
Prof. Dr. Roland Lang
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.