Special Issue "Cell and Molecular Biology of Pancreatic Disorders"
Deadline for manuscript submissions: closed (31 August 2018).
2. Department of Tumor Biology, Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Interests: calcium signaling; proteases in cancer; novel therapeutics in pancreatic cancer; cell cycle regulation; signal transduction; epithelial–mesenchymal transition; mechanisms of neurodegeneration; Alzheimer’s disease
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: Cell and Molecular Biology of Pancreatic Disorders 2019
Special Issue in International Journal of Molecular Sciences: Advances in Pancreatic Cancer Research: Underlying Mechanisms and Therapeutic Targets
Interests: molecular mechanisms that regulate cell proliferation; tumor progression; angiogenesis and metastasis; the role of nicotine in promoting growth and metastasis of tumors; cancer stem cells; mechanisms of drug resistance; novel drug targets
Special Issues and Collections in MDPI journals
This Special Issue is a continuation of our 2016 Special Issue, "Pancreatic Disorders".
Elucidation of the molecular mechanisms underlying the initiation and progression of a disease enables the development of targeted therapies to inhibit or delay the disease progression. Pancreatic disorders are of varying nature, with pancreatic ductal adenocarcinoma being one of the most lethal cancers, with a dismal five-year survival rate of less than 6%. Due to a lack of non-invasive early detection methods, the cancer is detected at a late stage when it is aggressive and resistant to available therapies. Additionally, the tumor microenvironment—enriched with growth factors and cytokines—significantly supports the growth and metastasis of tumor, and hinders the therapeutic efficacy. Secreted factors can act at the autocrine or paracrine level to promote or suppress cell growth in the microenvironment. Identification of the signaling mechanisms is important for targeted drug development. Furthermore, the role of cancer stem cells or tumor initiating cells in the genesis and progression of pancreatic cancer is also not fully elucidated. This special thematic issue is expected to cover the molecular and cellular mechanisms associated with pancreatic ductal adenocarcinomas, as well as the contribution of pancreatitis to the genesis of this disease. Other relevant aspects like the contribution of microenvironmental factors, cancer stem cells, behavior correlates such as smoking, and role of environmental pollutants in genesis and progression as well as response to therapy will be covered in this issue. We expect that this Special Issue will provide the latest information on the underlying mechanisms and treatment strategies associated with pancreatic disorders, and would be of interest to scientists and clinicians working in this area.
Prof. Dr. Jaya Padmanabhan
Prof. Dr. Srikumar Chellappan
Manuscript Submission Information
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- Pancreatic ductal adenocarcinoma
- Pancreatic neuroendocrine tumors
- Pancreatic intraepithelial neoplasia
- Intraductal papillary mucinous neoplasms
- Pancreatic cancer stem cells
- Pancreatic stromal cells
- Pancreatic microenvironment
- Genetic changes
- Transcription and translation
- Cell metabolism
- Intracellular and intercellular signaling