Special Issue "Cell and Molecular Biology of Pancreatic Disorders 2019"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 August 2019).
Interests: pancreas; liver; stomach; esophagus; gallbladder
2. Department of Tumor Biology, Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Interests: calcium signaling; proteases in cancer; novel therapeutics in pancreatic cancer; cell cycle regulation; signal transduction; epithelial–mesenchymal transition; mechanisms of neurodegeneration; Alzheimer’s disease
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: Cell and Molecular Biology of Pancreatic Disorders
Special Issue in International Journal of Molecular Sciences: Advances in Pancreatic Cancer Research: Underlying Mechanisms and Therapeutic Targets
This Special Issue is a continuation of our 2018 Special Issue, “Cell and Molecular Biology of Pancreatic Disorders”.
Elucidation of the molecular mechanisms underlying the initiation and progression of a disease enables the development of targeted therapies to inhibit or delay the disease progression. Pancreatic disorders vary in nature, with pancreatic ductal adenocarcinoma being one of the most lethal cancers, with a dismal five-year survival rate of less than 6%. Due to a lack of non-invasive early detection methods, the cancer is detected at a late stage when it is aggressive and resistant to available therapies. Additionally, the tumor microenvironment—enriched with growth factors and cytokines—significantly supports the growth and metastasis of tumors, and hinders therapeutic efficacy. Secreted factors can act at the autocrine or paracrine level to promote or suppress cell growth in the microenvironment. Identification of the signaling mechanisms is important for targeted drug development. Furthermore, the role of cancer stem cells or tumor-initiating cells in the genesis and progression of pancreatic cancer is also not fully elucidated. This Special Issue is expected to cover the molecular and cellular mechanisms associated with pancreatic ductal adenocarcinomas, as well as the contribution of pancreatitis to the genesis of this disease. Other relevant aspects like the contribution of microenvironmental factors, cancer stem cells, behavior correlates such as smoking, and the role of environmental pollutants in the genesis and progression as well as responses to therapy will be covered in this Issue. We expect that this Special Issue will provide the latest information on the underlying mechanisms and treatment strategies associated with pancreatic disorders, and will be of interest to scientists and clinicians working in this area.
Prof. Dr. Emmanuel E. Zervos
Prof. Dr. Jaya Padmanabhan
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- Pancreatic ductal adenocarcinoma
- Pancreatic neuroendocrine tumors
- Pancreatic intraepithelial neoplasia
- Intraductal papillary mucinous neoplasms
- Pancreatic cancer stem cells
- Pancreatic stromal cells
- Pancreatic microenvironment
- Genetic changes
- Transcription and translation
- Cell metabolism
- Intracellular and intercellular signaling
- Chronic pancreatitis
- Acute necrotizing pancreatitis