Next Article in Journal
Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings
Previous Article in Journal
Combined Therapy with SS31 and Mitochondria Mitigates Myocardial Ischemia-Reperfusion Injury in Rats
Previous Article in Special Issue
New Hope for Pancreatic Ductal Adenocarcinoma Treatment Targeting Endoplasmic Reticulum Stress Response: A Systematic Review
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(9), 2783; https://doi.org/10.3390/ijms19092783

Mesenchymal Stem Cells as New Therapeutic Approach for Diabetes and Pancreatic Disorders

Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy
*
Author to whom correspondence should be addressed.
Received: 8 August 2018 / Revised: 5 September 2018 / Accepted: 14 September 2018 / Published: 16 September 2018
(This article belongs to the Special Issue Cell and Molecular Biology of Pancreatic Disorders)
Full-Text   |   PDF [1452 KB, uploaded 16 September 2018]   |  

Abstract

Diabetes is a worldwide disease which actually includes different disorders related to glucose metabolism. According to different epidemiological studies, patients affected by diabetes present a higher risk to develop both acute and chronic pancreatitis, clinical situations which, in turn, increase the risk to develop pancreatic cancer. Current therapies are able to adjust insulin levels according to blood glucose peak, but they only partly reach the goal to abrogate the consequent inflammatory milieu responsible for diabetes-related diseases. In recent years, many studies have investigated the possible use of adult mesenchymal stem cells (MSCs) as alternative therapeutic treatment for diabetes, with promising results due to the manifold properties of these cells. In this review we will critically analyze the many different uses of MSCs for both diabetes treatment and for the reduction of diabetes-related disease development, focusing on their putative molecular mechanisms. View Full-Text
Keywords: diabetes; acute pancreatitis; chronic pancreatitis; pancreatic cancer; mesenchymal stem cells diabetes; acute pancreatitis; chronic pancreatitis; pancreatic cancer; mesenchymal stem cells
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Scuteri, A.; Monfrini, M. Mesenchymal Stem Cells as New Therapeutic Approach for Diabetes and Pancreatic Disorders. Int. J. Mol. Sci. 2018, 19, 2783.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top