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Special Issue "Carbohydrate Polymers for Pharmaceutical Applications"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 31 December 2019.

Special Issue Editors

Dr. Eneko Larrañeta
E-Mail Website
Guest Editor
Queen's University Belfast, School of Pharmacy, Belfast, United Kingdom
Interests: polymeric drug delivery systems; medical nanotechnology; characterization of nanoparticles; nanoparticle interactions with biological objects; hydrogels; transdermal drug delivery system; microneedle; medical devices
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Aim: The 21st century offers vast challenges for researchers around the globe, especially regarding the effective use of carbohydrate polymers as a new innovative class of biomaterials for biomedical and pharmaceutical applications. Different types of carbohydrate polymers can be engineered with desired structures and suitable physical and chemical properties that are of prime interest in a wide range of biomedical applications as diverse as drug delivery, controlled release, drug physical modification, tissue engineering, therapeutics, functional biomimetic scaffolds, regenerative dentistry diagnostics, microbial biofilms and many more. Thus, this Special Issue will summarize the recent development in the field of carbohydrate polymers to illustrate the new development of biomaterials for a number of applications.

Scope: This Special Issue will publish high quality short communications, research papers covering the most recent advances, as well as comprehensive reviews addressing novel and state-of-the-art topics from active researchers in biomaterials concerning not only the synthesis, preparation and characterization, but especially focusing on different aspects of pharmaceutical applications.

Dr. Vijay Kumar Thakur
Dr. Eneko Larrañeta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carbohydrate polymers
  • biodegradable polymers
  • biosensors
  • hydrogels
  • biomimetic
  • membranes
  • temperature-responsive polymers
  • shape-memory polymers
  • pH-responsive polymers
  • diagnosis
  • cancer therapy
  • molecular imprinting
  • drug delivery

Published Papers (2 papers)

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Research

Open AccessArticle
Anti-Diabetic Nephropathy Activities of Polysaccharides Obtained from Termitornyces albuminosus via Regulation of NF-κB Signaling in db/db Mice
Int. J. Mol. Sci. 2019, 20(20), 5205; https://doi.org/10.3390/ijms20205205 - 21 Oct 2019
Abstract
Termitornyces albuminosus is a kind of traditional Chinese edible fungus rich in nutrients and medicinal ingredients, and it has anti-oxidative, analgesic and anti-inflammatory effects. However, the hypoglycemic and nephroprotective effects of polysaccharides separated from T. albuminosus (PTA) have not been reported. The properties [...] Read more.
Termitornyces albuminosus is a kind of traditional Chinese edible fungus rich in nutrients and medicinal ingredients, and it has anti-oxidative, analgesic and anti-inflammatory effects. However, the hypoglycemic and nephroprotective effects of polysaccharides separated from T. albuminosus (PTA) have not been reported. The properties of PTA were analyzed in a BKS.Cg-Dock7m +/+ Leprdb/JNju (db/db) mouse model of diabetes. After the administration of PTA for eight weeks, the hypoglycemic and hypolipidemic activities of PTA in the db/db mice were assessed. The results of a cytokine array combined with an enzyme-linked immunosorbent assay confirmed the anti-oxidative and anti-inflammatory activities of PTA. An eight-week administration of PTA caused hypoglycemic and hypolipidemic functioning, as indicated by suppressed plasma glucose levels, as well as the modulation of several cytokines related to glycometabolism, in the sera and kidneys of the mice. PTA treatment also had a protective effect on renal function, restoring renal structures and regulating potential indicators of nephropathy. In the kidneys of the db/db mice, PTA treatment reduced the activation of protein kinase B, the inhibitor of κB kinase alpha and beta, and the inhibitor of κB alpha and nuclear factor-κB (NF-κB). We establish the hypoglycemic, hypolipidemic, and anti-diabetic nephropathy effects of PTA, and we find that the renal protection effects of PTA may be related to anti-inflammatory activity via the regulation of NF-κB signaling. Full article
(This article belongs to the Special Issue Carbohydrate Polymers for Pharmaceutical Applications)
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Open AccessArticle
Differential Susceptibility of Catheter Biomaterials to Biofilm-Associated Infections and Their Remedy by Drug-Encapsulated Eudragit RL100 Nanoparticles
Int. J. Mol. Sci. 2019, 20(20), 5110; https://doi.org/10.3390/ijms20205110 - 15 Oct 2019
Abstract
Biofilms are the cause of major bacteriological infections in patients. The complex architecture of Escherichia coli (E. coli) biofilm attached to the surface of catheters has been studied and found to depend on the biomaterial’s surface properties. The SEM micrographs and [...] Read more.
Biofilms are the cause of major bacteriological infections in patients. The complex architecture of Escherichia coli (E. coli) biofilm attached to the surface of catheters has been studied and found to depend on the biomaterial’s surface properties. The SEM micrographs and water contact angle analysis have revealed that the nature of the surface affects the growth and extent of E. coli biofilm formation. In vitro studies have revealed that the Gram-negative E. coli adherence to implanted biomaterials takes place in accordance with hydrophobicity, i.e., latex > silicone > polyurethane > stainless steel. Permanent removal of E. coli biofilm requires 50 to 200 times more gentamicin sulfate (G-S) than the minimum inhibitory concentration (MIC) to remove 90% of E. coli biofilm (MBIC90). Here, in vitro eradication of biofilm-associated infection on biomaterials has been done by Eudragit RL100 encapsulated gentamicin sulfate (E-G-S) nanoparticle of range 140 nm. It is 10–20 times more effective against E. coli biofilm-associated infections eradication than normal unentrapped G-S. Thus, Eudragit RL100 mediated drug delivery system provides a promising way to reduce the cost of treatment with a higher drug therapeutic index. Full article
(This article belongs to the Special Issue Carbohydrate Polymers for Pharmaceutical Applications)
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