Cancer Cell Biology and Drug Discovery 2.0

Dear Colleagues,

In order to develop novel anticancer therapies, it is essential to understand the pathogenesis of cancer and the biological basis of cancer cells. Various adjuvant and alternative therapies recently reported in the literature are attributable to the reduced quality of life associated with traditional cancer treatment. This requires a multidisciplinary approach in biology, physics, chemistry and computer science. Non‑thermal plasma technology has been considered as a new frontier in plasma medicine, in order to aid in the treatment of cancers. Plasma technology is relatively new to the field of medicine. Much experimental work, conducted at several major universities, research centers, and companies around the world over the recent decade, has determined that plasma can be used in a variety of medical applications as a plasma medicine. It is already widely used in surgeries and endoscopic procedures. Recently, a deeper understanding of the various mechanisms by which plasma can interact with biological systems, including the effects of reactive nitrogen species, reactive oxygen species, and charges, has begun to emerge. It was recently reported that this process begins  by the induction of apoptosis and feroptosis through various signaling pathways, such as p53, MAPK and c-myc. In addition, it is possible to discover novel lead compounds for cancer treatment, with excellent potential to be applied in the discovery of new natural compounds, through computer simulation and predictive analysis of physiological activity.

For this Special Issue, to be published in the International Journal of Molecular Science, researchers who are active in all aspects of novel applications of cancer therapy and drug development are invited to submit their latest results. Papers covering fundamental studies, as well as papers discussing applications, are welcome.

Prof. Dr. Ihn Han
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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• cancer biology
• drug discovery
• atmospheric nonthermal plasma
• reactive oxygen species
• reactive nitrogen species
• redox response
• c-myc
• p53
• p38 MAPK
• in silico
• microbial inactivation
• sterilization
• phytochemical
• oriental medicine