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Molecular Insights into Gynecologic Endocrinology and Reproductive Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 January 2025) | Viewed by 1550

Special Issue Editor

Special Issue Information

Dear Colleagues,

The field of gynecologic endocrinology and reproductive medicine is confronted with a myriad of complex diseases that significantly impact women's health and quality of life. Among these, endometriosis, polycystic ovary syndrome, uterine fibroids, and cervical cancer stand out as prevalent conditions requiring innovative diagnostic and therapeutic approaches. This Special Issue aims to highlight the latest molecular insights into these diseases, fostering the development of more accurate diagnostic tools and targeted therapies. We invite submissions that delve into the underlying molecular mechanisms, identify novel biomarkers for early detection, and evaluate the clinical efficacy of emerging treatments. 

All contributions, either reviews, meta-analyses or original research articles related to our topic “Gynecologic Endocrinology and Reproductive Medicine” are welcome to this Special Issue of the International Journal of Molecular Sciences. 

Prof. Dr. René Wenzl
Guest Editor

Manuscript Submission Information

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Keywords

  • gynecological diseases
  • endometriosis
  • polycystic ovary syndrome
  • uterine fibroids
  • cervical cancer
  • diagnosis
  • treatment
  • biomarkers
  • targeted therapies

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Published Papers (2 papers)

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Review

15 pages, 730 KiB  
Review
Endometriosis: Challenges in Clinical Molecular Diagnostics and Treatment
by Pedro Rosendo-Chalma, Erick Nicolás Díaz-Landy, Verónica Antonio-Véjar, Jonnathan Gerardo Ortiz Tejedor, Claudia Reytor-González, Daniel Simancas-Racines and Gabriele Davide Bigoni-Ordóñez
Int. J. Mol. Sci. 2025, 26(9), 3979; https://doi.org/10.3390/ijms26093979 - 23 Apr 2025
Viewed by 521
Abstract
Endometriosis is a chronic disease affecting approximately 10% (190 million) of women and girls of reproductive age worldwide. It is associated with a variety of often debilitating symptoms, including severe pelvic pain, pain during intercourse, bowel movements and/or urination, bloating, nausea, fatigue, risk [...] Read more.
Endometriosis is a chronic disease affecting approximately 10% (190 million) of women and girls of reproductive age worldwide. It is associated with a variety of often debilitating symptoms, including severe pelvic pain, pain during intercourse, bowel movements and/or urination, bloating, nausea, fatigue, risk of infertility, as well as depression and anxiety in some cases. This review summarized the pathogenesis of endometriosis and the criteria for clinical diagnosis, proposed a panel of potential biomarkers for predictive molecular diagnosis, as well as choice of treatments for pain and infertility management. Full article
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13 pages, 771 KiB  
Review
Maternal Hyperandrogenemia and the Long-Term Neuropsychological, Sex Developmental, and Metabolic Effects on Offspring
by Menelaos Darlas, Sophia Kalantaridou and Georgios Valsamakis
Int. J. Mol. Sci. 2025, 26(5), 2199; https://doi.org/10.3390/ijms26052199 - 28 Feb 2025
Viewed by 733
Abstract
Maternal hormonal and metabolic disorders, such as diabetes and obesity, can adversely affect the intrauterine environment, resulting in suboptimal fetal growth and an elevated risk of cardiovascular and metabolic diseases in the later life of the offspring. In this review, we examine the [...] Read more.
Maternal hormonal and metabolic disorders, such as diabetes and obesity, can adversely affect the intrauterine environment, resulting in suboptimal fetal growth and an elevated risk of cardiovascular and metabolic diseases in the later life of the offspring. In this review, we examine the long-term impact of elevated maternal androgen levels during pregnancy on offspring. Maternal hyperandrogenemia is linked to various neurodevelopmental disorders, including attention-deficit/hyperactivity disorder, autism spectrum disorder, and anxiety-like behaviors, mediated by alterations in key brain regions responsible for emotion and cognition. Furthermore, children born to mothers with hyperandrogenemia exhibit heightened risk of metabolic and cardiovascular dysfunctions, such as obesity, insulin resistance, and hypertension, which can manifest early in life. Prenatal exposure to androgens has also been linked to reduced birth weights and altered fetal growth, potentially due to impaired placental function. Additionally, maternal testosterone levels influence offspring sex ratios, often favoring male births, though exceptions occur in certain conditions, such as congenital adrenal hyperplasia. The findings of this review underscore the need for healthcare professionals to monitor maternal serum androgen profiles during pregnancy. Further research is needed to determine underlying mechanisms and potential interventions to mitigate these risks. Full article
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