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Advances in Brain Arteriovenous Malformation Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (31 July 2019) | Viewed by 5371

Special Issue Editors

Department of Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
Interests: neurovascular diseases; cerebrovascular diseases; cardiovascular diseases; brain AVMs; angiogenesis; vascular inflammation; thrombosis
Special Issues, Collections and Topics in MDPI journals
Department of Neurosurgery, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, 00100 Rome, Italy
Interests: cerebrovascular diseases; brain AVMs; brain aneurysms; cerebral cavernous angiomas; angiogenesis

Special Issue Information

Dear Colleagues,

Arteriovenous malformations (AVMs) are tangles of dysplastic vessels fed by arteries and drained by veins without intervening capillaries, forming a high-flow, low-resistance shunt between the arterial and venous systems. Recent findings from animal models and genetic studies suggest that brain AVMs, which were long considered congenital, arise from aberrant vasculogenesis and/or angiogenesis, probably upon subclinical injuries of the brain in predisposed individuals. In this Special Issue, we will publish articles focused on recent advances in the pathophysiology of brain AVMs. Preference will be given to original research articles on the genetic, epigenetic, and molecular mechanisms underlying AVM formation, including, but not limited to, the role of aberrant angiogenesis and vasculogenesis, angiogenic growth factors, and inflammation. Studies using animal models and innovative experimental techniques will also be welcome. We will also accept articles on recent advances in the diagnosis and therapy of brain AVMs, such as studies on novel imaging strategies, anti-angiogenic treatments, and robot-assisted surgery. Outstanding reviews and meta-analysis will also be considered.

Assoc. Prof. Roberto Pola
Dr. Carmelo Lucio Sturiale
Guest Editors

Manuscript Submission Information

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Keywords

  • brain arteriovenous malformation
  • angiogenesis
  • vasculogenesis
  • animal models
  • gene -expression
  • GWAS
  • inflammation
  • growth factors
  • hemorrhagic risk
  • diagnosis
  • therapy
  • review
  • meta-analysis

Published Papers (1 paper)

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Review

12 pages, 464 KiB  
Review
Recent Advances in Basic Research for Brain Arteriovenous Malformation
by Leandro Barbosa Do Prado, Chul Han, S. Paul Oh and Hua Su
Int. J. Mol. Sci. 2019, 20(21), 5324; https://doi.org/10.3390/ijms20215324 - 25 Oct 2019
Cited by 31 | Viewed by 5038
Abstract
Arteriovenous malformations (AVMs) are abnormal connections of vessels that shunt blood directly from arteries into veins. Rupture of brain AVMs (bAVMs) can cause life-threatening intracranial bleeding. Even though the majority of bAVM cases are sporadic without a family history, some cases are familial. [...] Read more.
Arteriovenous malformations (AVMs) are abnormal connections of vessels that shunt blood directly from arteries into veins. Rupture of brain AVMs (bAVMs) can cause life-threatening intracranial bleeding. Even though the majority of bAVM cases are sporadic without a family history, some cases are familial. Most of the familial cases of bAVMs are associated with a genetic disorder called hereditary hemorrhagic telangiectasia (HHT). The mechanism of bAVM formation is not fully understood. The most important advances in bAVM basic science research is the identification of somatic mutations of genes in RAS-MAPK pathways. However, the mechanisms by which mutations of these genes lead to AVM formation are largely unknown. In this review, we summarized the latest advance in bAVM studies and discussed some pathways that play important roles in bAVM pathogenesis. We also discussed the therapeutic implications of these pathways. Full article
(This article belongs to the Special Issue Advances in Brain Arteriovenous Malformation Research)
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