Special Issue "New Beta-Lactams, Beta-Lactamase Inhibitors and Targets for Beta-Lactamase Production Blockade: Powerful Allies against Multidrug-Resistant Pathogens"
Deadline for manuscript submissions: 31 May 2021.
Interests: nosocomial gram-negative pathogens; antibiotic resistance; peptidoglycan biology; host-pathogen interaction; virulence; cell-wall-targeting immunity
Antibiotic resistance, especially referred to nosocomial opportunistic bacterial pathogens, is already an undeniable threat for public health worldwide, with obvious clinical and economic consequences. In the specific context of beta-lactam antibiotics, the threat is certainly not less severe, given their generalized use. Nevertheless, the appearance of new therapeutic options brings us a reason for hope. Among these therapeutic allies, we acknowledge: (i) the appearance of novel beta-lactam-related drugs (such as cefiderocol or ceftobiprole); (ii) the use of new antibiotic combinations including beta-lactamase activity inhibitors (for instance ceftazidime/avibactam, ceftolozane/tazobactam, imipenem/relebactam, and meropenem-vaborbactam), and (iii) the research on unexplored targets leading to the blockade of intrinsic beta-lactamases production (usually related to cell wall metabolism, such as AmpG or NagZ proteins, which have been shown to be essential for the correct expression of intrinsic beta-lactamases and full virulence in Pseudomonas aeruginosa and related species). Reviews and research papers related to these topics (referring to either Gram-positive or Gram-negative pathogens) are welcome for this Special Issue.
Dr. Carlos Juan Nicolau
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Antibiotic resistance
- ESKAPE pathogens
- Acinetobacter baumannii
- Pseudomonas aeruginosa
- horizontally acquired beta-lactamases
- beta-lactamase inhibitors
- intrinsic beta-lactamases
- peptidoglycan recycling
- cell wall metabolism
- AmpC cephalosporinase