Special Issue "New Types of Antibacterial Biocides"
Deadline for manuscript submissions: 30 November 2022 | Viewed by 933
Today, the development of new highly effective antiseptics, disinfectants, and materials that bestow antimicrobial activity, environmental safety, and relatively low toxicity is of exceptional importance for significant areas of chemistry and materials science. The SARS-CoV-2 (COVID-19) pandemic, which began in 2020, has contributed to a sharp increase in the use of disinfectants, which multiply the risk of developing bacterial resistance and could lead to a sharp decrease in the effectiveness of biocidal in the future. A separate challenge for the scientific community is the ability of microorganisms to organize themselves into biofilms, i.e., a structured community in a self-produced polymeric matrix. The formation of biofilms is a global problem affecting various spheres of life. Thus, biofilms cause up to 80% of chronic human bacterial infections, and contribute to the development of microbial tolerance to traditional drugs and multidrug resistance. The ever-increasing number of resistant bacterial strains is of great concern, because if this problem is left unaddressed, by 2050, antimicrobial resistance (AMR) could claim more lives than cancer.
In general, there are two main strategies for combating biofilms: preventing their formation or destroying/removing already formed biofilm. Amino acids and antimicrobial peptides, metal chelators, quorum sensing inhibitors, surfactants, and other antibiofilm agents can be effectively used at different stages of biofilm formation.
The aim of the Special Issue is to review recent research on the synthesis and application of new antibacterial biocides. Full articles, short communications, and reviews are accepted for publication in the Special Issue.
Prof. Dr. Anatoly N. Vereshchagin
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- tantimicrobial biocides
- bacterial resistance
- microbial biofilms
- quaternary ammonium compounds
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
（1）Title: In-vitro bioactivity and antibacterial effects of a silver-containing mesoporous bioactive glass film on the surface of titanium implants
Author: Prof. Dr. Chi-Jen Shih
Abstract: Peri-implantitis is defined as the bacterial infection-induced inflammation and suppuration of soft and hard tissues surrounding a dental implant. If bacteria further invade the alveolar bone, they can easily cause bone loss and even lead to the early failure of a dental implant surgery. In the present study, an 80SiO2-15CaO-5P2O5 mesoporous bioactive glass film system containing 1, 5, and 10 mol% of silver was prepared on titanium implant discs (MBG-Ag-coated Ti) using sol-gel and spin coating methods. The wettability and adhesion strength of the films were evaluated using contact angle measurements and adhesion strength tests, respectively. The phase composition, chemical bonding, morphology, and oxidation states of the films were analyzed via X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS). In vitro bioactivity analysis of the films was performed by immersion in a simulated body fluid (SBF) for 24 h. Disk diffusion tests were performed on the early colonizing bacteria Aggregatibacter actinomycetemcomitans (A. a.) and Streptococcus mutans (S. m.) to evaluate the antibacterial ability of the films. A silver-containing mesoporous bioactive glass film with excellent biocompatibility and antibacterial properties was successfully prepared.
（2）Title: The development of a new suspension formation of amoxicillin and baicalein combination and its pharmacokinetics, residue elimination, and clinical efficacy trails in cows
Tingting Chen, Minyi Qian, Shusheng Tang, Chongshan Dai*
College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, P. R. China.
Staphylococcus aureus (S. aureus)-caused bovine mastitis and its antimicrobial resistance have posed a serious global concern. In the present study, our results that combination between amoxicillin (AMO) and baicalein (BAI) exhibited a synergistic antibacterial effect against S. aureus. Furthermore, a new suspension formation of AMO (5.5 % w/w mass)-BAI (5.5 % w/w mass) was developed and its pharmacokinetics, residue elimination, and clinical efficacy were studied. Total 24 udder quarters (from 6 health cows) were intramammary administered dosing with 5 g suspension formation of AMO-BAI per time in each udder quarter for 3 times (12 h-interval for each time). The pharmacokinetic parameters of AMO and BAI were calculated by using a non-compartmental model. The results showed that the t1/2 and Tmax of AMO and BAI were at 11.31±7.38 h and 6.82±2.23 h, respectively; and the Tmax of AMO and BAI were both at 1 h. The Cmax of AMO and BAI were 509.93±158.74 μg/mL and 128.41±80.50 μg/mL, respectively. Total 80 udder quarters (from 20 health cows) were used for the residue test of AMO and BAI, the results showed that the concentration of AMO in milk has decreased to about 10 ng/mL or less after the last administration 36 h; and AMO and BAI in milk have not been detected after the last administration 54 h. Furthermore, compared to the positive control (i.e, Synulox® LC), clinical trials data from 50 infected udder quarters (from 38 cows infected S. aureus) showed that AMO-BAI suspension formation showed a similar effect on sensitive S. aureus infection, but significantly improved its cure rate on resistant S. aureus (i.e., MRSA) infection (i.e., 60% vs 20%). Taken together, this is the first report of a new AMO-BAI suspension formation, which has a potential application the for preventing and treating S. aureus -caused cow mastitis.
Key words: Staphylococcus aureus; baicalein; amoxicillin; clinical efficacy; pharmacokinetics
Title: Green synthesized Iodophors as antimicrobial agents
Author: Dr. Zehra Edis