Genetics of Favourable Adiposity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 4990
Special Issue Editor
Special Issue Information
Dear Colleague,
Obesity is a major risk factor for cardiometabolic diseases including type 2 diabetes, heart disease and hypertension. However, two obese people of the same height and weight can have very different risks of the condition. As obesity increases, we need to understand more about why some people develop type 2 diabetes at lower weight and why some people stay healthy despite being obese. Recent genetic studies have identified genetic variants associated with higher adiposity but a healthier metabolic profile, including higher HDL-cholesterol, lower triglycerides, higher sex hormone binding globulin, lower alanine transaminase, and lower risk of type 2 diabetes, heart disease and hypertension. These variants were named ‘favourable adiposity’ due to their paradoxical associations with adiposity and risk of type 2 diabetes. One possible mechanism for these paradoxical associations has been identified to be a better storage capacity in subcutaneous adipose tissue which protects important organs including the liver from ectopic fat.
The aim of this Special Issue is to advance our knowledge of the mechanisms that make two people of the same age, sex and BMI have very different risks of type 2 diabetes, heart disease or hypertension. We seek to aggregate contributions in the forms of original papers and reviews on the following topics:
- Genetics of ‘favourable’ and ‘unfavourable’ adiposity.
- Mendelian randomization studies investigating the causal role of higher adiposity on disease risk.
- Genetics of fat distribution, including subcutaneous fat, visceral fat and ectopic fat and their role in disease mechanism.
- Genetic and/or epidemiological characteristics of obese but healthy people.
- The role of fat distribution in ethnic difference in the risk of type 2 diabetes, coronary artery disease and hypertension.
- Fat tissue function, obesity and risk of type 2 diabetes.
Dr. Hanieh Yaghootkar
Guest Editor
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