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Prostate Cancer: From Molecular Diagnosis to Treatment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (20 December 2024) | Viewed by 3426

Special Issue Editor


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Guest Editor
Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 00161 Rome, Italy
Interests: oncology; drug delivery; prostate cancer

Special Issue Information

Dear Colleagues,

Prostate cancer is a multifaceted and biologically highly heterogeneous disease, with widely varying levels of mortality and morbidity. Many patients present with an indolent disease with few symptoms, while others develop a highly aggressive disease that progresses to metastatic carcinoma that is refractory to both hormone therapy and chemotherapy.

This disease is the most common cancer in men and the second leading cause of cancer deaths. Despite the great progress made in the field of prostate cancer research and treatment, further integrated analyses are still required to better understand the biology of prostate cancer and to identify new biomarkers in order to determine the diagnosis, prognosis and targeted therapeutic options for patients.

This Special Issue invites manuscripts analysing the genome, epigenome and transcriptome that are associated with the initiation and progression of prostate cancer from indolent to malignant status, as well as therapeutic responses. In addition, we are interested in publishing analyses of novel target therapies.

Dr. Ida Silvestri
Guest Editor

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Keywords

  • prostate cancer
  • molecular profiling
  • prostate cancer diagnosis
  • precision target therapy

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Published Papers (1 paper)

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Review

38 pages, 2896 KiB  
Review
The Emerging Predictive and Prognostic Role of Aggressive-Variant-Associated Tumor Suppressor Genes Across Prostate Cancer Stages
by Martino Pedrani, Jessica Barizzi, Giuseppe Salfi, Alessandro Nepote, Irene Testi, Sara Merler, Luis Castelo-Branco, Ricardo Pereira Mestre, Fabio Turco, Luigi Tortola, Jean-Philippe Theurillat, Silke Gillessen and Ursula Vogl
Int. J. Mol. Sci. 2025, 26(1), 318; https://doi.org/10.3390/ijms26010318 - 1 Jan 2025
Cited by 2 | Viewed by 2663
Abstract
Aggressive variant prostate cancer (AVPC) is characterized by a molecular signature involving combined defects in TP53, RB1, and/or PTEN (AVPC-TSGs), identifiable through immunohistochemistry or genomic analysis. The reported prevalence of AVPC-TSG alterations varies widely, reflecting differences in assay sensitivity, treatment pressure, [...] Read more.
Aggressive variant prostate cancer (AVPC) is characterized by a molecular signature involving combined defects in TP53, RB1, and/or PTEN (AVPC-TSGs), identifiable through immunohistochemistry or genomic analysis. The reported prevalence of AVPC-TSG alterations varies widely, reflecting differences in assay sensitivity, treatment pressure, and disease stage evolution. Although robust clinical evidence is still emerging, the study of AVPC-TSG alterations in prostate cancer (PCa) is promising. Alterations in TP53, RB1, and PTEN, as well as the combined loss of AVPC-TSGs, may have significant implications for prognosis and treatment. These biomarkers might help predict responses to various therapies, including hormonal treatments, cytotoxic agents, radiotherapy, and targeted therapies. Understanding the impact of these molecular alterations in patients with PCa is crucial for personalized management. In this review, we provide a comprehensive overview of the emerging prognostic and predictive roles of AVPC-TSG alterations across PCa stages. Moreover, we discuss the implications of different methods used for detecting AVPC-TSG alterations and summarize factors influencing their prevalence. As our comprehension of the genomic landscape of PCa disease deepens, incorporating genomic profiling into clinical decision making will become increasingly important for improving patient outcomes. Full article
(This article belongs to the Special Issue Prostate Cancer: From Molecular Diagnosis to Treatment)
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