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Recent Advances in Biomedical Nanocomposites and Their Functionalizations

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 719

Special Issue Editor


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Guest Editor
School of Natural Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW 2109, Australia
Interests: nanoparticles; nanocapsules; nanogels; nanofibers; nanocomposites; nanocoatings
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

To date, nanostructures in various forms, including inorganic/organic nanoparticles, nanocapsules, nanogels, nanofibers, nanocomposites, and even nanocoatings, have been designed and developed. These nanostructures can have intrinsic antibacterial/anticancer properties or can be used as nanocarriers for loading molecules/biomolecules with antibacterial/anticancer effects.

The last decade has seen advances in the design of these nanocarriers, not only in their synthesis but also in surface functionalization approaches. Through this progress, various characterization techniques have also been employed to indicate their successful synthesis as well as the successful loading of active molecules. These nanocarriers have been used for the treatment of cancer as well as infections from the in vitro to in vivo level.

Moreover, different theoretical modelling/calculation/simulation methods, including density functional theory, molecular docking, molecular dynamics, Monte Carlo, etc., have been used to investigate the interactions at the molecular level, leading to new insights into nanocarrier design.

Suggested topics include, but are not limited to:

  • The synthesis of various forms of nanostructures with intrinsic antibacterial/anticancer effects.
  • The synthesis of various forms of nanostructures as nanocarriers with antibacterial/anticancer properties.
  • The surface functionalization of nanocarriers for enhanced selectivity.
  • Multifunctional nanocarriers.
  • In vitro, in vivo, and in silico studies on nanocarriers.
  • Stability in biological media.
  • Nanocarriers with synergistic therapeutic effects.
  • Nanocarriers with theragnostic effects.

Dr. Mohammad Tavakkoli Yaraki
Guest Editor

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Keywords

  • nanocarrier
  • drug delivery
  • nanoparticle
  • nanocapsules
  • nanogel
  • nanofiber
  • nanocomposite
  • nanocoating
  • cancer treatment
  • therapy
  • infection

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Published Papers (1 paper)

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Research

11 pages, 4681 KiB  
Article
ZIF-8 as a pH-Responsive Nanoplatform for 5-Fluorouracil Delivery in the Chemotherapy of Oral Squamous Cell Carcinoma
by Jessica Hao, Chider Chen, Kresimir Pavelic and Fusun Ozer
Int. J. Mol. Sci. 2024, 25(17), 9292; https://doi.org/10.3390/ijms25179292 - 27 Aug 2024
Viewed by 311
Abstract
5-fluorouracil (5-FU), a chemotherapeutic agent against oral squamous cell carcinoma (OSCC), is limited by poor pharmacokinetics and toxicity. The pH-sensitive zeolite imidazolate framework-8 (ZIF-8) may increase the selectivity and length of 5-FU released into the acidic tumor microenvironment. This study examined the in [...] Read more.
5-fluorouracil (5-FU), a chemotherapeutic agent against oral squamous cell carcinoma (OSCC), is limited by poor pharmacokinetics and toxicity. The pH-sensitive zeolite imidazolate framework-8 (ZIF-8) may increase the selectivity and length of 5-FU released into the acidic tumor microenvironment. This study examined the in vitro 5-FU absorption and release profiles of ZIF-8, and then progressed to cytotoxicity assays using the OSCC primary cell line SCC7. The 5-FU loading capacity of ZIF-8 was calculated with UV-vis spectroscopy (λ = 260 nm). 5-FU release was quantified by submerging 5-FU@ZIF-8 in pH 7.4 and 5.5 acetate buffer over 48 h. For the cytotoxicity assays, 5-FU, ZIF-8, and 5-FU@ZIF-8 were added to SCC7 cultures at 25, 50, and 100 μg/mL. Cell viability was assessed through toluidine blue staining and further quantified through transcriptomic RNA sequencing. ZIF-8 stabilized at a maximum absorption of 2.71 ± 0.22 mg 5-FU, and released 0.66 mg more 5-FU at pH 5.5 than 7.4 for at least 72 h. The cytotoxicity assays showed that 5-FU@ZIF-8 had a synergistic inhibitory effect at 50 μg/mL. The RNA sequencing analysis further revealed the molecular targets of 5-FU@ZIF-8 in SCC7. 5-FU@ZIF-8 may release 5-FU based on the pH of the surrounding microenvironments and synergistically inhibit OSCC. Full article
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