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Molecular Mechanism in DNA Replication and Repair

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 104

Special Issue Editor


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Guest Editor
Institute of Health Sciences, The John Paul II Catholic University of Lublin, Kostantynów 1 H Str., 20-708 Lublin, Poland
Interests: cancer; genomics; molecular biology; health sciences

Special Issue Information

Dear Colleagues,

DNA replication, i.e., making a copy of a cell’s DNA, is a process in which approximately 3 billion base pairs of DNA in the genome must be properly copied when any of the cells divide. DNA replication is semiconservative, which means that each strand in the DNA double helix is a template for the synthesis of a complementary strand. Cells copy their DNA in a fast way, and they use multiple enzymes and proteins in this process, including DNA polymerase, DNA primase, DNA helicase, DNA ligase, and topoisomerase. DNA polymerase could make mistakes while adding nucleotides. Most of the mistakes are corrected during replication, but when it is not employed, the mismatch repair mechanism is implemented, which replaces the incorrect bases with the proper ones. Another type of repair is nucleotide excision repair, which removes incorrect bases along with a few bases on the 3′ and 5′ ends and replaces them by copying the template using DNA polymerase. Most of the mistakes are corrected; uncorrected bases result in mutations, which may cause multiple consequences, such as cancer.

This Special Issue of IJMS is dedicated to understanding and expanding the knowledge of molecular and cellular mechanisms of DNA replication and repair. This Special Issue is supervised by Dr. Ryszard Maciejewski and assisted by our Topical Advisory Panel Member, Dr. Julita Machlowska (Medical University of Lublin). We would like to create a platform for multiple research projects and publications on different aspects of DNA replication and repair mechanisms, which might be significant in terms of novel disease therapies.

Prof. Dr. Ryszard Maciejewski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • DNA replication
  • genome stability
  • DNA repair mechanisms
  • mismatch repair mechanism
  • nucleotide excision repair
  • cancer risk

Published Papers

This special issue is now open for submission.
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