Cognitive Dysfunction: Molecular Research and Novel Therapy

Dear Colleagues,

Normal aging is an inevitable process of organisms over time. Brain aging is one of the most critical biological processes disturbing the physiological balance, and cognitive impairment including Alzheimer’s disease (AD) is one of the most common and disabling conditions in older people. Cognitive impairment is characterized by a considerable reduction in neural activity or neuronal death in the brain. Dementia refers to the loss of an individual’s mental abilities and ability to perform social activities severe enough to cause a person daily life impairment. Despite recent FDA-approved drug for AD, it is still equivocal in that of clinical effectiveness, and new therapeutic approaches are needed.

This Special Issue will present the current research approaches to understand the progression of cognitive impairment and external environment of the brain excavation according to controllable changes. This Issue will also present research on the identification of the changes in immune cells in the brain to control targets aggravating dementia due to lipid metabolism problems in the blood, to discover risk factors and early diagnostic biomarkers for dementia in other body organs outside the brain, and to explore therapeutic targets controlling cognitive impairment. We warmly welcome contributions in the form of original research articles, reviews, and communications.

Dr. KyoungJoo Cho
Guest Editor

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