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Analytical Methods in Biomedical and Environmental Applications: A Molecular Approach (2nd Edition)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 1134

Special Issue Editor


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Guest Editor
Faculty of Medicine, Transilvania University of Brasov, 40268 Brasov, Romania
Interests: diagnostic and therapeutic biomarker investigation; laboratory medicine; novel clinical molecular diagnostic methods development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Analytical methods are essential in both biomedical and environmental fields, with a molecular approach providing precise insights. By examining molecular structures and interactions, these methods allow for a thorough understanding and evaluation of biological and environmental systems. Whether detecting or releasing biomarkers in clinical samples, examining nutrients in foods or assessing pollutants in natural ecosystems, the molecular perspective empowers researchers to uncover valuable information crucial for advancing healthcare, food and environmental management.

For this Special Issue, “Analytical Methods in Biomedical and Environmental Applications: A Molecular Approach 2.0”, we invite manuscripts addressing the following topics:

  • The development of novel methods for the identification and quantification of key (bio)molecules across various sample types.
  • The detection of trace amounts of analytes and strategies for handling complex matrices such as food, biological or environmental samples.
  • The tailoring of material and molecular structures, coupled with analyses of mechanisms, kinetics and thermodynamics.
  • Computational studies are also of significant interest.

We encourage colleagues to share their scientific achievements through original research focusing on the development, evaluation, simulation and use of various methodologies/platforms for the detection of different compounds in complex samples. We also welcome studies investigating delivery systems for the controlled release of drugs, novel food additives and functional ingredients, agrochemicals and nutrients, aiming to enhance medical treatment, food and its flavor, and crop yield and quality, while minimizing environmental impacts. Review articles should provide an up-to-date and state-of-the-art overview of the analytical methods implemented in the topic areas covered. Research on microfluidics and microdevices in point-of-care testing, optical fibers, electrodes of new materials, surface functionalization strategies or any other molecular approach to detect or release molecules in food, biological and environmental samples is particularly welcome, including topics beyond those listed here.

Please feel free to contact us and send us suggestions of work that you would like to discuss beforehand. We are looking forward to receiving your contributions and welcome your participation in this Special Issue.

Dr. Monica Florescu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • analytical methods
  • molecular
  • delivery systems
  • controlled release
  • diagnosis
  • treatment
  • medicine
  • food
  • crop yield
  • food additives
  • functional ingredients
  • environment

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Related Special Issue

Published Papers (2 papers)

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Research

14 pages, 11803 KiB  
Article
An Acylhydrazone Fluorescent Sensor: Bifunctional Detection of Thorium (IV) and Vanadyl Ions over Uranyl and Lanthanide Ions
by Xin Lin, Hua Liang, Ke Dai, Jing Zhou, Qiang Tian, Yuge Xiang, Zhicheng Guo and László Almásy
Int. J. Mol. Sci. 2025, 26(7), 3231; https://doi.org/10.3390/ijms26073231 - 31 Mar 2025
Viewed by 275
Abstract
Thorium is a notable candidate for resolving uranium shortage caused by the global application of nuclear power generation. Uranium extraction from seawater is another attempt to handle its source deficiency, however, vanadium is one of the main competitive elements in that process. Exploration [...] Read more.
Thorium is a notable candidate for resolving uranium shortage caused by the global application of nuclear power generation. Uranium extraction from seawater is another attempt to handle its source deficiency, however, vanadium is one of the main competitive elements in that process. Exploration of probes which can discriminatively detect thorium and vanadium from uranium has primary significance for their further separation and for environmental protection. Herein, N′-(2,4-dihydroxybenzylidene)-4-hydroxylphenylhydrazide, AOH, is used as sensor for Th4+ and vanadyl (VO2+) determination. AOH demonstrates a specific “turn-on” fluorescence selectivity towards Th4+ over f-block and other foreign metal ions, with a detection limit (LOD) of 7.19 nM in acidic solution and a binding constant of 9.97 × 109 M−2. Meanwhile, it shows a “turn-off” fluorescence response towards VO2+ over other metal ions at the coexistence of Th4+, with a LOD of 0.386 μM in the same media and a binding constant of 4.54 × 104 M−1. The recognition mechanism, based on HRMS, 1H NMR, and FT-IR results, demonstrates that VO2+ causes the fluorescence quenching by replacing Th4+ to coordinate with AOH. In real water detection tests, Th4+ and VO2+ exhibited satisfying recoveries. These findings expand the application of sensors in nuclide pollution control. Full article
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13 pages, 2766 KiB  
Article
Headspace Extraction onto a 3D-Printed Device for GC-MS Quantification of Polychlorinated Biphenyls in Newborn Urine
by Paweł Georgiev, Mariusz Belka, Szymon Ulenberg, Dagmara Kroll, Bartosz Marciniak, Izabela Drążkowska, Tomasz Bączek and Justyna Płotka-Wasylka
Int. J. Mol. Sci. 2025, 26(6), 2755; https://doi.org/10.3390/ijms26062755 - 19 Mar 2025
Viewed by 189
Abstract
Polychlorinated biphenyls (PCBs) are persistent organic pollutants that pose significant health risks, especially for neonates. Traditional urine analysis methods for PCBs are often complex and prone to contamination. This study introduces a novel, efficient, and contamination-free method for PCB analysis in neonatal urine [...] Read more.
Polychlorinated biphenyls (PCBs) are persistent organic pollutants that pose significant health risks, especially for neonates. Traditional urine analysis methods for PCBs are often complex and prone to contamination. This study introduces a novel, efficient, and contamination-free method for PCB analysis in neonatal urine using 3D-printed extraction devices. A headspace extraction method was developed, utilizing a 3D-printed device containing C18-modified silica particles. Urine samples were heated to 90 °C, and volatile PCBs were sorbed onto the particles. The method was optimized for maximum extraction efficiency and selectivity, demonstrating excellent linearity, precision, and accuracy. The optimized method was successfully applied to analyze neonatal urine samples, revealing detectable levels of PCBs. This innovative approach, leveraging 3D-printed devices, offers a promising solution for sample preparation, minimizing contamination risks and enabling the analysis of volatile compounds. The customizable nature of 3D-printed devices opens up possibilities for future advancements in environmental analysis. Full article
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