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Advanced Biochemical Research: Transcription in Cancer Initiation and Progression

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 14283

Special Issue Editor


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Guest Editor
Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland
Interests: transcription; epigenetics; PARP1; SWI/SNF; EP300; differentiation; cancerogenesis; chromatin; transcription factors; transcription co-factors
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Special Issue Information

Dear Colleagues,

The transformation of normal healthy cells into cancer cells is a complex multistep process, mostly associated with the de-differentiation of specialized cells, the re-entrance of G0/G1-arrested cells to mitotic divisions, the ability to spread and invade tissues, as well as immortality. Although the initiation of carcinogenesis is linked with mutations and a loss of genomic stability, the following promotion and progression steps require alteration also in other “-omics”. Transcriptional reprogramming adapts the proteome of the transforming cell to new phenotypes by facilitating a gradual decrease in the expression of cell type or highly specific tissue genes, and by enhancing the expression of factors that promote proliferation, migration, and metastases.

Our issue is dedicated to the elucidation of the essential transcription-relevant events that contribute to carcinogenesis, and to the identification of emerging hubs where gene transcription and malignancy interact with each other. Therefore, we invite submissions that cover genome-wide as well as gene-specific chromatin remodeling that accompanies all stages of tumor development. We aim to identify transcription factors, co-factors, nucleosome readers, writers, and erasers that drive cell transformation. Our Specials Issue also aims to publish papers dealing with the molecular basis of oncogene expression, the repression of tumor suppressors, the role of cell cycle progression, and E2F-dependent gene transcription in gaining the cancer phenotype. Likewise, we are particularly interested in all aspects dealing with transcription of factors, which make malignant cells resistant to anti-cancer approaches.

Dr. Agnieszka Zdzislawa Robaszkiewicz
Guest Editor

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Keywords

  • cancer
  • transcription
  • transcription factors and co-factors
  • chromatin remodeling
  • epigenetic modification
  • oncogenes
  • suppressors
  • cell cycle
  • E2F-dependent gene transcription
  • tumor resistance
  • signaling

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Published Papers (3 papers)

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Research

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19 pages, 5304 KiB  
Article
NCOA7 Regulates Growth and Metastasis of Clear Cell Renal Cell Carcinoma via MAPK/ERK Signaling Pathway
by Jiayu Guo, Shuai Ke, Qi Chen, Jiangqiao Zhou, Jia Guo and Tao Qiu
Int. J. Mol. Sci. 2023, 24(14), 11584; https://doi.org/10.3390/ijms241411584 - 18 Jul 2023
Cited by 7 | Viewed by 1740
Abstract
NCOA7 is a nuclear receptor coactivator that is downregulated in a variety of cancers. However, the expression and prognostic significance of NCOA7 in clear cell renal cell carcinoma (ccRCC) remain unknown. The expression of NCOA7 in ccRCC tissues was analyzed using bioinformatics analysis, [...] Read more.
NCOA7 is a nuclear receptor coactivator that is downregulated in a variety of cancers. However, the expression and prognostic significance of NCOA7 in clear cell renal cell carcinoma (ccRCC) remain unknown. The expression of NCOA7 in ccRCC tissues was analyzed using bioinformatics analysis, Western blotting, and immunohistochemistry. Kaplan–Meier analysis, the receiver operating characteristic (ROC) curve, and clinicopathological correlation analysis were used to assess the predictive power of NCOA7. Overexpression function tests were conducted in cells and mouse models to clarify the function and mechanism of NCOA7 in inhibiting the progression of ccRCC. NCOA7 expression was downregulated in all three subtypes of renal cell carcinoma, and only had significant prognostic value for patients with ccRCC. NCOA7 overexpression inhibited the proliferation, invasion, and metastasis of ccRCC cells in vivo and in vitro. Mechanistically, NCOA7 inhibited the MAPK/ERK pathway to regulate epithelial–mesenchymal transformation (EMT) and apoptosis, thereby inhibiting the progression of ccRCC. NCOA7 inhibits tumor growth and metastasis of ccRCC through the MAPK/ERK pathway, thus indicating its potential as a prognostic marker and therapeutic target for ccRCC. Full article
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Review

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12 pages, 1558 KiB  
Review
Transcription Factor MYB as Therapeutic Target: Current Developments
by Karl-Heinz Klempnauer
Int. J. Mol. Sci. 2024, 25(6), 3231; https://doi.org/10.3390/ijms25063231 - 12 Mar 2024
Cited by 1 | Viewed by 1553
Abstract
The MYB protein is a pivotal player in the cellular transcriptional network, influencing major important processes such as cell proliferation, differentiation, and apoptosis. Because of its role in oncogenesis, MYB is now a compelling target for therapeutic interventions in cancer research. This review [...] Read more.
The MYB protein is a pivotal player in the cellular transcriptional network, influencing major important processes such as cell proliferation, differentiation, and apoptosis. Because of its role in oncogenesis, MYB is now a compelling target for therapeutic interventions in cancer research. This review summarizes its molecular functions and current therapeutic approaches aiming to inhibit its oncogenic activity. Full article
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Other

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7 pages, 653 KiB  
Opinion
Concern about the Effectiveness of mRNA Vaccination Technology and Its Long-Term Safety: Potential Interference on miRNA Machinery
by Gianmarco Stati, Paolo Amerio, Mario Nubile, Silvia Sancilio, Francesco Rossi and Roberta Di Pietro
Int. J. Mol. Sci. 2023, 24(2), 1404; https://doi.org/10.3390/ijms24021404 - 11 Jan 2023
Cited by 3 | Viewed by 9003
Abstract
After the outbreak of the pandemic due to COVID-19 infection, several vaccines were developed on short timelines to counteract the public health crisis. To allow the administration of mRNA vaccines through a faster-paced approval process, the Emergency Use Authorization (EUA) was applied. The [...] Read more.
After the outbreak of the pandemic due to COVID-19 infection, several vaccines were developed on short timelines to counteract the public health crisis. To allow the administration of mRNA vaccines through a faster-paced approval process, the Emergency Use Authorization (EUA) was applied. The Ba.5 (omicron) variant of SARS-CoV-2 is the predominant one at this moment. Its highly mutable single-stranded RNA genome, along with its high transmissivity, generated concern about the effectiveness of vaccination. The interaction between the vaccine and the host cell is finely regulated by miRNA machinery, a complex network that oversees a wide range of biological processes. The dysregulation of miRNA machinery has been associated with the development of clinical complications during COVID-19 infection and, moreover, to several human pathologies, among which is cancer disease. Now that in some areas, four doses of mRNA vaccine have been administered, it is natural to wonder about its effectiveness and long-term safety. Full article
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