Advanced Biochemical Research: Transcription in Cancer Initiation and Progression
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 March 2025 | Viewed by 14283
Special Issue Editor
Interests: transcription; epigenetics; PARP1; SWI/SNF; EP300; differentiation; cancerogenesis; chromatin; transcription factors; transcription co-factors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The transformation of normal healthy cells into cancer cells is a complex multistep process, mostly associated with the de-differentiation of specialized cells, the re-entrance of G0/G1-arrested cells to mitotic divisions, the ability to spread and invade tissues, as well as immortality. Although the initiation of carcinogenesis is linked with mutations and a loss of genomic stability, the following promotion and progression steps require alteration also in other “-omics”. Transcriptional reprogramming adapts the proteome of the transforming cell to new phenotypes by facilitating a gradual decrease in the expression of cell type or highly specific tissue genes, and by enhancing the expression of factors that promote proliferation, migration, and metastases.
Our issue is dedicated to the elucidation of the essential transcription-relevant events that contribute to carcinogenesis, and to the identification of emerging hubs where gene transcription and malignancy interact with each other. Therefore, we invite submissions that cover genome-wide as well as gene-specific chromatin remodeling that accompanies all stages of tumor development. We aim to identify transcription factors, co-factors, nucleosome readers, writers, and erasers that drive cell transformation. Our Specials Issue also aims to publish papers dealing with the molecular basis of oncogene expression, the repression of tumor suppressors, the role of cell cycle progression, and E2F-dependent gene transcription in gaining the cancer phenotype. Likewise, we are particularly interested in all aspects dealing with transcription of factors, which make malignant cells resistant to anti-cancer approaches.
Dr. Agnieszka Zdzislawa Robaszkiewicz
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer
- transcription
- transcription factors and co-factors
- chromatin remodeling
- epigenetic modification
- oncogenes
- suppressors
- cell cycle
- E2F-dependent gene transcription
- tumor resistance
- signaling
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.