T-Cell Lymphoma: From Basic Science to Novel Therapeutics

Dear Colleagues,

T-cell lymphomas are a heterogeneous and aggressive group of non-Hodgkin lymphomas originating from mature T cells. Despite advances in our understanding of their molecular and clinical features, outcomes remain poor for many subtypes, and current treatment options are often limited and non-curative. There is a pressing need for novel therapeutic strategies that are both more effective and tailored to the biological complexity of these malignancies.

This Special Issue aims to provide a comprehensive overview of the latest advances in T-cell lymphoma research, from basic mechanistic insights to translational and clinical developments. We welcome original research articles, reviews, and short communications focusing on the pathobiology of T-cell lymphomas, novel molecular targets, innovative treatment approaches including cellular therapies and immunotherapy, and biomarker-driven strategies for patient stratification and outcome prediction. Studies regarding real-world clinical management are also highly encouraged.

By bringing together contributions from both basic and clinical researchers, this issue seeks to foster a deeper understanding of T-cell lymphoma and support the development of more effective and personalized therapeutic interventions.

We would like to acknowledge Dr Carlo Gentile (Pathological Anatomy Unit, “Renato Dulbecco” Hospital) for his participation as Guest Editor Assistant in the development of this Special Issue.

Dr. Daniele Caracciolo
Dr. Andrea Duminuco
Guest Editors

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