The Function of Mitochondrial Metabolism in Heart and Skeletal Muscle
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1549
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mitochondria are often called the "powerhouses" of the cell because they play a critical role in producing the energy needed for cellular processes. This is particularly important in tissues with high energy demands, such as the heart and skeletal muscle.
In the heart, mitochondrial metabolism is essential for maintaining normal cardiac function. The heart relies heavily on oxidative metabolism to generate ATP, which is the primary energy source for cardiac muscle contraction. Mitochondrial dysfunction has been linked to numerous cardiac pathologies, including heart failure and arrhythmias. In addition to ATP production, mitochondria in the heart also play essential roles in calcium handling, reactive oxygen species (ROS) generation, and apoptosis.
Similarly, skeletal muscle also requires high levels of ATP to sustain muscle contraction during exercise. Mitochondria in skeletal muscle are critical for generating this ATP through oxidative phosphorylation. Additionally, mitochondrial metabolism in skeletal muscle is essential for regulating glucose and lipid metabolism, maintaining redox balance, contractile function, and regulating cell signaling pathways.
In both the heart and skeletal muscle, mitochondrial dysfunction can lead to impaired metabolism and energy production, contributing to the development of numerous pathologies, including heart failure and muscle dysfunction. Therefore, maintaining healthy mitochondrial function is crucial for the proper function of these tissues.
Papers related to any aspect of mitochondrial and energy metabolism in the heart and skeletal muscle and clinical reports will be considered for this Special Issue.
Dr. Yoshitake Cho
Guest Editor
Manuscript Submission Information
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Keywords
- heart
- skeletal muscle
- metabolism
- glucose
- mitochondria
- metabolic disorder
