Pattern Recognition Receptors in Gastrointestinal Inflammation and Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (25 February 2023) | Viewed by 2361
Special Issue Editors
Interests: cell signaling; diet and metabolic disorders; gastrointestinal inflammation and cancer; gut microbiome; host–pathogen interaction; NOD-like receptors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The host immune system is equipped with various pattern recognition receptors (PRRs), which sense pathogen- or danger-associated molecular patterns at the cell surface or inside the cell. PPRs, including toll-like receptors (TLRs), NOD-like receptors (NLRs), retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), and nucleic acid sensors, play critical roles in host defense against infections and inflammatory disorders. Genetic and experimental studies have linked gastrointestinal disorders, such as inflammatory bowel diseases, colorectal cancer, and liver diseases, to dysfunction in several PRRs. It appears that TLRs, NLRs, and other PRRs provide protection against these diseases through the regulation of various cell signaling pathways, immune responses, physiological functions, and gut microbiota composition. This Special Issue aims to collect original research and review articles representing recent advances on the role of different PRRs in colitis, colorectal cancer, and other gastrointestinal disorders.
Dr. Hasan Zaki
Dr. Christopher Lupfer
Guest Editors
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Keywords
- pattern recognition receptors
- toll-like receptors (TLRs)
- NOD-like receptors (NLRs)
- RIG-I-like receptors
- AIM2
- DNA sensors
- colitis
- colorectal cancer
- gastrointestinal inflammation
- inflammatory bowel diseases
- gut microbiota
- host–pathogen interaction
- inflammatory disorders
- hepatocellular carcinoma
- fatty liver syndrome
- immunopathology
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