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Calcium Homeostasis and Dynamics in Life and Health
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Calcium Homeostasis and Dynamics in Life and Health

A topical collection in International Journal of Molecular Sciences (ISSN 1422-0067). This collection belongs to the section "Biochemistry".

Viewed by 964

Editor

Prof. Dr. Youjun Wang

E-Mail Website
Collection Editor
Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China
Interests: Ca2+ signaling
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

Calcium ions (Ca2+) are fundamental to nearly every facet of both animal and plant life. The intricate and dynamic spatiotemporal fluctuations of Ca2+ concentration, or Ca2+ signals, play a crucial role in regulating processes such as synaptic transmission, kinase or lipase activity, gene expression, cell migration, immune response, muscle contraction, development, and aging. Disruptions in Ca2+ signals and homeostasis can lead to a range of serious diseases, including immune and neurological disorders, cardiovascular diseases, and more. To discover new actors, novel regulation mechanisms, or the pathophysiological roles of existing Ca2+ signaling pathways, researchers are developing and employing advanced tools, conducting comprehensive omics analyses, and visualizing or manipulating Ca2+ signals at the subcellular, cellular, and in vivo levels. This Topical Collection “Calcium Homeostasis and Dynamics in Life and Health” invites submissions of original research or reviews on the development of Ca2+-related tools, pathways, cellular processes, and disease mechanisms in both animals and plants. We encourage scientists from all disciplines to contribute their latest and most exciting findings in this critical area of study.

Prof. Dr. Youjun Wang
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • calcium ions (Ca2+)
  • Ca2+ homeostasis
  • immune disorders
  • neurological disorders
  • cardiovascular diseases
  • stress
  • plant-pathogen interaction
  • development
  • pollen tube growth

Published Papers (1 paper)

2024

21 pages, 2396 KiB  
Article
TP53I11 Functions Downstream of Multiple MicroRNAs to Increase ER Calcium Levels and Inhibits Cancer Cell Proliferation
by Yiping Wang, Shuai Zhang, Jie Bing, Wanjie Li, Lin Sun and Youjun Wang
Int. J. Mol. Sci. 2025, 26(1), 31; https://doi.org/10.3390/ijms26010031 - 24 Dec 2024
Viewed by 755
Abstract
Cells meticulously regulate free calcium ion (Ca2+) concentrations, with the endoplasmic reticulum (ER) being crucial for Ca2+ homeostasis. Disruptions in ER Ca2+ balance can contribute to various diseases, including cancer. Although considerable research has focused on the direct mechanisms [...] Read more.
Cells meticulously regulate free calcium ion (Ca2+) concentrations, with the endoplasmic reticulum (ER) being crucial for Ca2+ homeostasis. Disruptions in ER Ca2+ balance can contribute to various diseases, including cancer. Although considerable research has focused on the direct mechanisms of ER Ca2+ regulation, the role of microRNAs (miRNAs) in this process remains underexplored. Mainly using data from a CRISPR-based genomic screening previously conducted in our laboratory, we identified 33 candidate miRNAs that may regulate ER Ca2+ levels. From these, 10 miRNAs were found to significantly lower basal ER Ca2+ levels. RNA sequencing analysis indicated that these miRNAs downregulate the tumor suppressor tumor protein p53 (TP53)-inducible protein 11 gene (TP53I11), which is a key regulator of ER Ca2+ levels. Functional assays confirmed that TP53I11 influences ER Ca2+ levels and affects cancer cell proliferation. Additionally, the chemotherapeutic agent doxorubicin (DOX) was shown to upregulate TP53I11 and enhance ER Ca2+ accumulation. These findings elucidate the central role of TP53I11 in miRNA-mediated regulation of ER Ca2+ homeostasis and suggest potential therapeutic strategies targeting ER Ca2+ upregulation for cancer intervention. Full article
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