Paradigm Shift in Central Nervous System Trauma: Molecular Targets and New Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 1408
Special Issue Editor
Interests: brain tumors; glioblastoma; drug delivery; nanobased delivery systems; neuroimaging; stem cells; antiangiogenetic drugs; preclinical animal models; cerebral blood flow imaging
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The mortality and high morbidity of traumatic CNS injury are associated with acute primary damage, chronically expanding into adjacent tissues as a result of a secondary cascade of pathological, neuroinflammatory, and immune-response events that inhibit CNS regeneration.
The result is neuronal and glial loss, reactive astrogliosis, local B-cell and microglial activation, and the synthesis of pathogenic autoantibodies. Research in this field has primarily looked for ways of targeting molecular mechanisms to prevent cell death, oxidative stress, and inflammation, but the focus has recently shifted to the CNS cells themselves as potential targets for CNS repair.
This Special Issue will provide a comprehensive overview of the molecular mechanisms and therapeutic approaches that aim not only to eliminate the inhibitory environment after traumatic CNS injury, but also to explore regenerative solutions, including via stem cells, gene therapy, autoimmune antibodies, and intermediate neural networks, to promote neural regeneration and neural circuit reconstruction.
Dr. Antonella Mangraviti
Guest Editor
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Keywords
- spinal cord injury
- traumatic brain injury
- regenerative medicine
- neuronal plasticity
- stem cell therapy
- autoimmune antibodies
- neuroinflammation
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