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Nanostructured Formulations in Pharmaceutical, Medical and Cosmetic Applications 2.0
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Nanostructured Formulations in Pharmaceutical, Medical and Cosmetic Applications 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 7241

Special Issue Editor

Dr. Urszula Bazylinska

E-Mail Website
Guest Editor
The Head of Nanocolloids and Disperse Systems Laboratory, Department of Physical and Quantum Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland
Interests: surfactants; disperse systems; colloids; nanoemulsions; lipid nanocarriers; polymeric nanocarriers; encapsulation/solubilization processes; colloidal stability; photodynamic therapy; theranostics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, many kinds of novel colloidal formulations of nanoscopic size with outstanding pharmaceutical, medical, and cosmetic potential have been investigated with an expansion in the design of a wide variety of “soft” and surface-modified nanostructures such as lipid-based or polymer-origin. For the both proposed groups of nanosystems, the rational design strategy in the self-organization of surfactants and lipids, as well as templating processes using polymers and co-polymers (including functionalized ones), should be applied, leading to the production of extremely colloidally stable, “intelligent”, and functional pharmaceutical or cosmetic forms.

This Special Issue focusses on the recent progress in the design, engineering, and physicochemical evaluation of novel nanostructured formulations and their potential in pharmaceutical, medical, and cosmetic applications. It will include research papers and review articles reflecting the most recent developments in this dynamic research area, including “soft” and surface-modified nanostructures such as lipid-based (vesicular and non-vesicular origin) and polymer-based (nanocapsules, nanomicelles, nanospheres, dendrimers, polymersomes, nanogels). Papers involving recent research and achievements in the fabrication of novel lipid–polymer and organic–inorganic nanohybrids are also welcome.

Due to the success of the 1st edition, we would like to add more results and new insights from recent research projects. You can find the 1st edition at the following link:
https://www.mdpi.com/journal/ijms/special_issues/Nanostructured_Formulations_Applications.

Dr. Urszula Bazylinska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • surfactants
  • disperse systems
  • colloids
  • nanoemulsions
  • lipid nanocarriers
  • polymeric nanocarriers
  • lyotropic liquid crystals
  • colloidal stability
  • drug delivery
  • self-organization
  • templating processes
  • encapsulation/solubilization processes
  • theranostics
  • nanohybrids

Related Special Issue

Published Papers (6 papers)

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Research

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18 pages, 7819 KiB  
Article
Fluoride-Incorporated Apatite Coating on Collagen Sponge as a Carrier for Basic Fibroblast Growth Factor
by Aniruddha Pal, Ayako Oyane, Maki Nakamura, Kenji Koga, Erika Nishida and Hirofumi Miyaji
Int. J. Mol. Sci. 2024, 25(3), 1495; https://doi.org/10.3390/ijms25031495 - 25 Jan 2024
Viewed by 719
Abstract
Coating layers consisting of a crystalline apatite matrix with immobilized basic fibroblast growth factor (bFGF) can release bFGF, thereby enhancing bone regeneration depending on their bFGF content. We hypothesized that the incorporation of fluoride ions into apatite crystals would enable the tailored release [...] Read more.
Coating layers consisting of a crystalline apatite matrix with immobilized basic fibroblast growth factor (bFGF) can release bFGF, thereby enhancing bone regeneration depending on their bFGF content. We hypothesized that the incorporation of fluoride ions into apatite crystals would enable the tailored release of bFGF from the coating layer depending on the layer’s fluoride content. In the present study, coating layers consisting of fluoride-incorporated apatite (FAp) crystals with immobilized bFGF were coated on a porous collagen sponge by a precursor-assisted biomimetic process using supersaturated calcium phosphate solutions with various fluoride concentrations. The fluoride content in the coating layer increased with the increasing fluoride concentration of the supersaturated solution. The increased fluoride content in the coating layer reduced its solubility and suppressed the burst release of bFGF from the coated sponge into a physiological salt solution. The bFGF release was caused by the partial dissolution of the coating layer and, thus, accompanied by the fluoride release. The concentrations of released bFGF and fluoride were controlled within the estimated effective ranges in enhancing bone regeneration. These findings provide useful design guidelines for the construction of a mineralized, bFGF-releasing collagen scaffold that would be beneficial for bone tissue engineering, although further in vitro and in vivo studies are warranted. Full article
(This article belongs to the Special Issue Nanostructured Formulations in Pharmaceutical, Medical and Cosmetic Applications 2.0)
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16 pages, 5307 KiB  
Article
Natural-Origin Betaine Surfactants as Promising Components for the Stabilization of Lipid Carriers
by Agata Pucek-Kaczmarek, Dominika Celary and Urszula Bazylińska
Int. J. Mol. Sci. 2024, 25(2), 955; https://doi.org/10.3390/ijms25020955 - 12 Jan 2024
Viewed by 724
Abstract
In the present work, we demonstrate studies involving the influence of the formulation composition on the physicochemical properties of nanocarriers: solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). Novel lipid-origin platforms were prepared using two “green” betaine-based surfactants, cocamidopropyl betaine (ROKAmina K30) [...] Read more.
In the present work, we demonstrate studies involving the influence of the formulation composition on the physicochemical properties of nanocarriers: solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). Novel lipid-origin platforms were prepared using two “green” betaine-based surfactants, cocamidopropyl betaine (ROKAmina K30) and coco betaine (ROKAmina K30B), in combination with three different solid lipids, cetyl palmitate (CRODAMOL CP), trimyristin (Dynasan 114), and tristearin (Dynasan 118). Extensive optimization studies included the selection of the most appropriate lipid and surfactant concentration for effective SLN and NLC stabilization. The control parameters involving the hydrodynamic diameters of the obtained nanocarriers along with the size distribution (polydispersity index) were determined by dynamic light scattering (DLS), while shape and morphology were evaluated by atomic force microscopy (AFM) and transmission electron microscopy (TEM). Electrophoretic light scattering (ELS) and turbidimetric method (backscattering profiles) were used to assess colloidal stability. The studied results revealed that both betaine-stabilized SLN and NLC formulations containing CRODAMOL CP as lipid matrix are the most monodisperse and colloidally stable regardless of the other components and their concentrations used, indicating them as the most promising candidates for drug delivery nanosystems with a diverse range of potential uses. Full article
(This article belongs to the Special Issue Nanostructured Formulations in Pharmaceutical, Medical and Cosmetic Applications 2.0)
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19 pages, 6223 KiB  
Article
Bovine Serum Albumin as a Platform for Designing Biologically Active Nanocarriers—Experimental and Computational Studies
by Olga Adamczyk, Magdalena Szota, Kamil Rakowski, Magdalena Prochownik, Daniel Doveiko, Yu Chen and Barbara Jachimska
Int. J. Mol. Sci. 2024, 25(1), 37; https://doi.org/10.3390/ijms25010037 - 19 Dec 2023
Viewed by 1072
Abstract
Due to the specificity of their structure, protein systems are adapted to carry various ligands. The structure of many proteins potentially allows for two types of immobilization of a therapeutic agent, either on the outer surface of the protein or within the protein [...] Read more.
Due to the specificity of their structure, protein systems are adapted to carry various ligands. The structure of many proteins potentially allows for two types of immobilization of a therapeutic agent, either on the outer surface of the protein or within the protein structure. The existence of two active sites in BSA’s structure, the so-called Sudlow I and II, was confirmed. The conducted research involved determining the effectiveness of BSA as a potential carrier of 5-fluorouracil (5FU). 5-fluorouracil is a broad-spectrum anticancer drug targeting solid tumors. The research was carried out to estimate the physicochemical properties of the system using complementary measurement techniques. The optimization of the complex formation conditions made it possible to obtain significant correlations between the form of the drug and the effective localization of the active substance in the structure of the protein molecule. The presence of two amino groups in the 5FU structure contributes to the deprotonation of the molecule at high pH values (pH > 8) and the transition to the anionic form (AN1 and AN3). To investigate the binding affinity of the tautomeric form with BSA, UV-vis absorption, fluorescence quenching, zeta potential, QCM-D, and CD spectroscopic studies were performed. The experimental research was supported by molecular dynamics (MD) simulations and molecular docking. The simulations confirm the potential location of 5FU tautomers inside the BSA structure and on its surface. Full article
(This article belongs to the Special Issue Nanostructured Formulations in Pharmaceutical, Medical and Cosmetic Applications 2.0)
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12 pages, 2529 KiB  
Article
Tailoring Properties of Hyaluronate-Based Core–Shell Nanocapsules with Encapsulation of Mixtures of Edible Oils
by Justyna Bednorz, Krzysztof Smela and Szczepan Zapotoczny
Int. J. Mol. Sci. 2023, 24(19), 14995; https://doi.org/10.3390/ijms241914995 - 08 Oct 2023
Viewed by 667
Abstract
Dispersions of core–shell nanocapsules (nanoemulsion) composed of liquid oil cores and polysaccharide-based shells were fabricated with emulsification using various mixtures of edible oils and amphiphilic hyaluronate derivatized with 12-carbon alkyl chains forming the shells. Such nanocapsules, with typical diameters in the 100–500 nm [...] Read more.
Dispersions of core–shell nanocapsules (nanoemulsion) composed of liquid oil cores and polysaccharide-based shells were fabricated with emulsification using various mixtures of edible oils and amphiphilic hyaluronate derivatized with 12-carbon alkyl chains forming the shells. Such nanocapsules, with typical diameters in the 100–500 nm range, have been previously shown as promising carriers of lipophilic bioactive compounds. Here, the influence of some properties of the oil cores on the size and stability of the capsules were systematically investigated using oil binary mixtures. The results indicated that, in general, the lower the density, viscosity, and interfacial tension (IFT) between the oil and aqueous polymer solution phases, the smaller the size of the capsules. Importantly, an unexpected synergistic reduction of IFT of mixed oils was observed leading to the values below the measured for individual oils. Such a behavior may be used to tailor size but also other properties of the nanocapsules (e.g., stability, solubility of encapsulated compounds) that could not be achieved applying just a single oil. It is in high demand for applications in pharmaceutical or food industries and opens opportunities of using more complex combinations of oils with more components to achieve an even further reduction of IFT leading to even smaller nanocapsules. Full article
(This article belongs to the Special Issue Nanostructured Formulations in Pharmaceutical, Medical and Cosmetic Applications 2.0)
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20 pages, 7803 KiB  
Article
Pharmaceutical Development of Nanostructured Vesicular Hydrogel Formulations of Rifampicin for Wound Healing
by Chantal M. Wallenwein, Verena Weigel, Götz Hofhaus, Namrata Dhakal, Wolfgang Schatton, Svetlana Gelperina, Florian K. Groeber-Becker, Jennifer Dressman and Matthias G. Wacker
Int. J. Mol. Sci. 2022, 23(24), 16207; https://doi.org/10.3390/ijms232416207 - 19 Dec 2022
Cited by 4 | Viewed by 2094
Abstract
Chronic wounds exhibit elevated levels of inflammatory cytokines, resulting in the release of proteolytic enzymes which delay wound-healing processes. In recent years, rifampicin has gained significant attention in the treatment of chronic wounds due to an interesting combination of antibacterial and anti-inflammatory effects. [...] Read more.
Chronic wounds exhibit elevated levels of inflammatory cytokines, resulting in the release of proteolytic enzymes which delay wound-healing processes. In recent years, rifampicin has gained significant attention in the treatment of chronic wounds due to an interesting combination of antibacterial and anti-inflammatory effects. Unfortunately, rifampicin is sensitive to hydrolysis and oxidation. As a result, no topical drug product for wound-healing applications has been approved. To address this medical need two nanostructured hydrogel formulations of rifampicin were developed. The liposomal vesicles were embedded into hydroxypropyl methylcellulose (HPMC) gel or a combination of hyaluronic acid and marine collagen. To protect rifampicin from degradation in aqueous environments, a freeze-drying method was developed. Before freeze-drying, two well-defined hydrogel preparations were obtained. After freeze-drying, the visual appearance, chemical stability, residual moisture content, and redispersion time of both preparations were within acceptable limits. However, the morphological characterization revealed an increase in the vesicle size for collagen–hyaluronic acid hydrogel. This was confirmed by subsequent release studies. Interactions of marine collagen with phosphatidylcholine were held responsible for this effect. The HPMC hydrogel formulation remained stable over 6 months of storage. Moving forward, this product fulfills all criteria to be evaluated in preclinical and clinical studies. Full article
(This article belongs to the Special Issue Nanostructured Formulations in Pharmaceutical, Medical and Cosmetic Applications 2.0)
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Review

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24 pages, 1788 KiB  
Review
Nanotechnology as a Promising Method in the Treatment of Skin Cancer
by Angelika A. Adamus-Grabicka, Pawel Hikisz and Joanna Sikora
Int. J. Mol. Sci. 2024, 25(4), 2165; https://doi.org/10.3390/ijms25042165 - 10 Feb 2024
Viewed by 1421
Abstract
The incidence of skin cancer continues to grow. There are an estimated 1.5 million new cases each year, of which nearly 350,000 are melanoma, which is often fatal. Treatment is challenging and often ineffective, with conventional chemotherapy playing a limited role in this [...] Read more.
The incidence of skin cancer continues to grow. There are an estimated 1.5 million new cases each year, of which nearly 350,000 are melanoma, which is often fatal. Treatment is challenging and often ineffective, with conventional chemotherapy playing a limited role in this context. These disadvantages can be overcome by the use of nanoparticles and may allow for the early detection and monitoring of neoplastic changes and determining the effectiveness of treatment. This article briefly reviews the present understanding of the characteristics of skin cancers, their epidemiology, and risk factors. It also outlines the possibilities of using nanotechnology, especially nanoparticles, for the transport of medicinal substances. Research over the previous decade on carriers of active substances indicates that drugs can be delivered more accurately to the tumor site, resulting in higher therapeutic efficacy. The article describes the application of liposomes, carbon nanotubes, metal nanoparticles, and polymer nanoparticles in existing therapies. It discusses the challenges encountered in nanoparticle therapy and the possibilities of improving their performance. Undoubtedly, the use of nanoparticles is a promising method that can help in the fight against skin cancer. Full article
(This article belongs to the Special Issue Nanostructured Formulations in Pharmaceutical, Medical and Cosmetic Applications 2.0)
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