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Molecular Research on Reproductive Toxicology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 5206

Special Issue Editor


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Guest Editor
Department of Biology, University Federico II, Via Cintia 21, 80126 Napoli, Italy
Interests: emerging contaminants; environmental toxicity; benzodiazepines; gametogenesis; embryo development; teratogenicity; oxidative stress; gene expression; behavioral alterations; histological alterations
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Special Issue Information

Dear Colleagues,

The contamination of surface water with pharmaceutical residues poses a growing environmental and ecological challenge. For decades, pharmaceutical compounds and their metabolites have been released into sewage systems, often with little regard for their effects on wild flora and fauna at both organismal and molecular levels.

This Special Issue will gather the latest research on disruptions caused by widely used pharmacological compounds, particularly disruptions affecting the reproductive processes of aquatic organisms. Psychotropic drugs, whose usage has surged in response to the global increase in stress-related conditions and the COVID-19 pandemic, are of special interest.

Submissions should focus on the molecular mechanisms underlying alterations in reproductive behavior, gametogenesis, fertilization, and embryonic development. We welcome studies that explore changes at the level of gene expression, signaling pathways, epigenetic modifications, and cellular receptor interactions induced by pharmaceutical contaminants.

Research on invertebrate and lower vertebrate species, often under-represented in toxicological studies, is especially encouraged. Additionally, for comparative purposes, we invite comprehensive reviews on mammalian reproduction (including human studies) that focus on biomolecular effects.

This Special Issue is supervised by Dr. Chiara Maria Motta and assisted by Dr. Chiara Fogliano (University Federico II).

Dr. Chiara Maria Motta
Guest Editor

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Keywords

  • environmental contamination
  • aquatic organisms
  • psychotropic drugs
  • gametogenesis
  • development
  • teratogenesis
  • gene expression
  • behavioral effects
  • oxidative stress
  • epigenotoxic effects
  • detoxification
  • bioaccumulation

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Published Papers (2 papers)

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16 pages, 5422 KiB  
Article
Benzodiazepine Interference with Fertility and Embryo Development: A Preliminary Survey in the Sea Urchin Paracentrotus lividus
by Chiara Fogliano, Rosa Carotenuto, Paola Cirino, Raffaele Panzuto, Martina Ciaravolo, Palma Simoniello, Ilaria Sgariglia, Chiara Maria Motta and Bice Avallone
Int. J. Mol. Sci. 2024, 25(4), 1969; https://doi.org/10.3390/ijms25041969 - 6 Feb 2024
Cited by 3 | Viewed by 2386
Abstract
Psychotropic drugs and benzodiazepines are nowadays among the primary substances of abuse. This results in a large and constant release into aquatic environments where they have potentially harmful effects on non-target organisms and, eventually, human health. In the last decades, evidence has been [...] Read more.
Psychotropic drugs and benzodiazepines are nowadays among the primary substances of abuse. This results in a large and constant release into aquatic environments where they have potentially harmful effects on non-target organisms and, eventually, human health. In the last decades, evidence has been collected on the possible interference of benzodiazepines with reproductive processes, but data are few and incomplete. In this study, the possible negative influence of delorazepam on fertilization and embryo development has been tested in Paracentrotus lividus, a key model organism in studies of reproduction and embryonic development. Sperm, eggs, or fertilized eggs have been exposed to delorazepam at three concentrations: 1 μg/L (environmentally realistic), 5 μg/L, and 10 μg/L. Results indicate that delorazepam reduces the fertilizing capacity of male and female gametes and interferes with fertilization and embryo development. Exposure causes anatomical anomalies in plutei, accelerates/delays development, and alters the presence and distribution of glycoconjugates such as N-Acetyl-glucosamine, α-linked fucose, and α-linked mannose in both morulae and plutei. These results should attract attention to the reproductive fitness of aquatic species exposed to benzodiazepines and pave the way for further investigation of the effects they may exert on human fertility. The presence of benzodiazepines in the aquatic environment raises concerns about the reproductive well-being of aquatic species. Additionally, it prompts worries regarding potential impacts on human fertility due to the excessive use of anxiolytics. Full article
(This article belongs to the Special Issue Molecular Research on Reproductive Toxicology)
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14 pages, 3090 KiB  
Article
Perfluorooctanoic Acid (PFOA) Exposure Compromises Fertility by Affecting Ovarian and Oocyte Development
by Han Zhang, Lulu Han, Lijun Qiu, Bo Zhao, Yang Gao, Zhangjie Chu and Xiaoxin Dai
Int. J. Mol. Sci. 2024, 25(1), 136; https://doi.org/10.3390/ijms25010136 - 21 Dec 2023
Cited by 5 | Viewed by 1753
Abstract
PFOA, a newly emerging persistent organic pollutant, is widely present in various environmental media. Previous reports have proved that PFOA exposure can accumulate in the ovary and lead to reproductive toxicity in pregnant mice. However, the potential mechanism of PFOA exposure on fertility [...] Read more.
PFOA, a newly emerging persistent organic pollutant, is widely present in various environmental media. Previous reports have proved that PFOA exposure can accumulate in the ovary and lead to reproductive toxicity in pregnant mice. However, the potential mechanism of PFOA exposure on fertility remains unclear. In this study, we explore how PFOA compromises fertility in the zebrafish. The data show that PFOA (100 mg/L for 15 days) exposure significantly impaired fertilization and hatching capability. Based on tissue sections, we found that PFOA exposure led to ovarian damage and a decrease in the percentage of mature oocytes. Moreover, through in vitro incubation, we determined that PFOA inhibits oocyte development. We also sequenced the transcriptome of the ovary of female zebrafish and a total of 284 overlapping DEGs were obtained. Functional enrichment analysis showed that 284 overlapping DEGs function mainly in complement and coagulation cascades signaling pathways. In addition, we identified genes that may be associated with immunity, such as LOC108191474 and ZGC:173837. We found that exposure to PFOA can cause an inflammatory response that can lead to ovarian damage and delayed oocyte development. Full article
(This article belongs to the Special Issue Molecular Research on Reproductive Toxicology)
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