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Selected Papers from 1-ICNTP, the First International Conference on Natural Toxicology and Pharmacology (Guangzhou, 2019)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 21869

Special Issue Editors


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Guest Editor
Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China
Interests: phytochemicals; phytosterol; phenylethanoid glycosides; polyphenols; natural products; antioxidants; metabolism; function foods; toxicology; risk assessment; stability
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Drug Sciences, University of Pavia, Pavia, Italy
Interests: food chemistry and analysis; food supplements; functional foods; chromatographic and spectrophotometric methods; natural compounds; polyphenols; antioxidant activity; anti- inflammatory activity; epigenetic effect of food components-mirnas; preclinical studies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is related to the First International Conference on Natural Toxicology and Pharmacology (1-ICNTP), which will be held in Guangzhou, August 8–12th, 2019. 1-ICNTP is jointly organized by Jinan University, Zhejiang University, University of Macau, and University of Hong Kong. 1-ICNTP is sponsored by the International Association of Dietetic Nutrition and Safety (IADNS) and the International Society for Chinese Medicine (ISCM).

In traditional Chinese medicines, the toxicology of many herbs, minerals, and animals has been widely applied to against diseases. Natural products-based drug discovery is still of great importance today, especially in some therapeutic areas. This Special Issue seeks updated and new knowledge on the chemical, bioactive, and toxicological aspects of natural products. This Special Issue will shape the future research direction for this important natural source. Our purpose is to feature high-quality, advanced research and knowledge contributed by various research groups from around the world working on phytochemicals. We invite researchers to contribute reviews and reports of their recent work on the chemistry, biology, and biotechnology of natural products.

Please note, registration for 1-ICNTP is obligatory for acceptance.

The Special Issue will focus on natural products, including following aspects:

  1. Natural products for the prevention and therapy of modern diseases.
  2. The mechanism of natural products for the therapy and chemoprevention of modern diseases.
  3. The importance of findings of natural products in medicine and food.
  4. QSAR and modeling for natural drug design.
  5. Natural antioxidants and human health.
  6. A new strategy of using natural products for managing diseases.
  7. Pharmacokinetics and the biotransformation of natural products.
  8. Delivery systems and the stability of natural products.
  9. Toxicology and the intake risk of natural products.

Prof. Dr. Baiyi Lu
Prof. Dr. Maria Daglia
Guest Editors

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Keywords

  • natural products
  • phytochemistry
  • phytomedicine
  • metabolism
  • prevention
  • chemoprevention
  • function food
  • pharmacokinetics
  • biotransformation
  • structure–activity relationships
  • toxicology

Published Papers (5 papers)

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Research

14 pages, 3261 KiB  
Article
Holothuria Leucospilota Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation
by Yiqiong Yuan, Qibing Liu, Fuqiang Zhao, Jun Cao, Xuanri Shen and Chuan Li
Int. J. Mol. Sci. 2019, 20(19), 4738; https://doi.org/10.3390/ijms20194738 - 24 Sep 2019
Cited by 48 | Viewed by 4415
Abstract
Holothuria leucospilota polysaccharides (HLP) are expected to become potential resources for the treatment of hyperlipidemia because of their various bioactivities. In the study, the treatment of HLP on improving hyperlipidemia in rats was explored. Oral administration of HLP at 100 or 200 mg/kg [...] Read more.
Holothuria leucospilota polysaccharides (HLP) are expected to become potential resources for the treatment of hyperlipidemia because of their various bioactivities. In the study, the treatment of HLP on improving hyperlipidemia in rats was explored. Oral administration of HLP at 100 or 200 mg/kg body weight effectively alleviated serum lipid levels and liver histological abnormalities in high-fat-diet rats. HLP regulated abnormal mRNA, lipogenesis-related hormones and inflammatory cytokines (tumor necrosis factor-α, interleukin-6 and interleukin-12) levels. HLP improved the ability of gut microbiota to produce short-chain fatty acids (SCFAs). SCFAs have been found to ameliorate liver lesions. Therefore, HLP alleviated hyperlipidemia by improving the levels of SCFAs to regulate lipid metabolism. These results indicated that HLP could be used as beneficial polysaccharides to alleviate hyperlipidemia. Full article
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14 pages, 1275 KiB  
Article
Feasibility of Laser-Induced Breakdown Spectroscopy and Hyperspectral Imaging for Rapid Detection of Thiophanate-Methyl Residue on Mulberry Fruit
by Di Wu, Liuwei Meng, Liang Yang, Jingyu Wang, Xiaping Fu, Xiaoqiang Du, Shaojia Li, Yong He and Lingxia Huang
Int. J. Mol. Sci. 2019, 20(8), 2017; https://doi.org/10.3390/ijms20082017 - 24 Apr 2019
Cited by 28 | Viewed by 3200
Abstract
An effective and rapid way to detect thiophanate-methyl residue on mulberry fruit is important for providing consumers with quality and safe of mulberry fruit. Chemical methods are complex, time-consuming, and costly, and can result in sample contamination. Rapid detection of thiophanate-methyl residue on [...] Read more.
An effective and rapid way to detect thiophanate-methyl residue on mulberry fruit is important for providing consumers with quality and safe of mulberry fruit. Chemical methods are complex, time-consuming, and costly, and can result in sample contamination. Rapid detection of thiophanate-methyl residue on mulberry fruit was studied using laser-induced breakdown spectroscopy (LIBS) and hyperspectral imaging (HSI) techniques. Principal component analysis (PCA) and partial least square regression (PLSR) were used to qualitatively and quantitatively analyze the data obtained by using LIBS and HSI on mulberry fruit samples with different thiophanate-methyl residues. The competitive adaptive reweighted sampling algorithm was used to select optimal variables. The results of model calibration were compared. The best result was given by the PLSR model that used the optimal preprocessed LIBS–HSI variables, with a correlation coefficient of 0.921 for the prediction set. The results of this research confirmed the feasibility of using LIBS and HSI for the rapid detection of thiophanate-methyl residue on mulberry fruit. Full article
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15 pages, 2789 KiB  
Article
Polysaccharides from the Edible Mushroom Agaricus bitorquis (Quél.) Sacc. Chaidam Show Anti-hypoxia Activities in Pulmonary Artery Smooth Muscle Cells
by Yingchun Jiao, Hui Kuang, Jianan Wu and Qihe Chen
Int. J. Mol. Sci. 2019, 20(3), 637; https://doi.org/10.3390/ijms20030637 - 1 Feb 2019
Cited by 14 | Viewed by 3481
Abstract
Three kinds of new water-soluble polysaccharides (FA, FB and FC) were isolated from wild mushroom Agaricus bitorquis (Quél.) Sacc. Chaidam by the classical method “water extraction and alcohol precipitation” and purified by column chromatography. The Mw of FA, FB and FC ranged from [...] Read more.
Three kinds of new water-soluble polysaccharides (FA, FB and FC) were isolated from wild mushroom Agaricus bitorquis (Quél.) Sacc. Chaidam by the classical method “water extraction and alcohol precipitation” and purified by column chromatography. The Mw of FA, FB and FC ranged from 5690 Da to 38,340 Da. The three polysaccharide fractions in the fruiting body were mainly composed of 4 kinds of monosaccharides, including glucose, galactose, mannose, and arabinose, among which glucose and galactose were the major monosaccharides. The FTIR and NMR spectroscopy indicated that the skeleton of three fractions composed of a (1→4)-α-D-glycosidic backbone containing α-D-mannopyranose. In vitro anti-hypoxia activity data showed that three polysaccharide fractions possessed a significant effect on inhibiting PASM cells apoptosis under hypoxia. Among them, FC at the concentration of 200 µg/mL revealed a significant anti-hypoxia effect. These results revealed that the intracellular polysaccharides possessed potent anti-hypoxic activity, which might be related to inhibiting LDH and NADPH oxidase expression and promoting the formation of 5-hydroxytryptamine, dopamine, endothelins, acetylcholine. More importantly, FC showed good performance inducing KV1.5 expression and prohibiting KIR6.2 formation at protein level. Full article
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11 pages, 2520 KiB  
Article
Role of Green Macroalgae Enteromorpha Prolifera Polyphenols in the Modulation of Gene Expression and Intestinal Microflora Profiles in Type 2 Diabetic Mice
by Guopeng Lin, Xiaoyan Liu, Xin Yan, Dan Liu, Chengfeng Yang, Bin Liu, Yifan Huang and Chao Zhao
Int. J. Mol. Sci. 2019, 20(1), 25; https://doi.org/10.3390/ijms20010025 - 21 Dec 2018
Cited by 63 | Viewed by 4600
Abstract
Effects of green macroalgae 55% ethanolic extract Enteromorpha prolifera through an ultrafiltration membrane of 3 kDa (EPE3k) on antidiabetic activity, gut microbiota, and regulation mechanism were investigated in high-fat/high-sucrose diet and streptozocin-induced diabetic mice. The structural characterizations of its major compounds in EPE3k [...] Read more.
Effects of green macroalgae 55% ethanolic extract Enteromorpha prolifera through an ultrafiltration membrane of 3 kDa (EPE3k) on antidiabetic activity, gut microbiota, and regulation mechanism were investigated in high-fat/high-sucrose diet and streptozocin-induced diabetic mice. The structural characterizations of its major compounds in EPE3k were determined by ultra-performance liquid chromatography-quadrupole/time of flight mass spectrometry. Furthermore, the intestinal microflora modulation in diabetic mice was also investigated with high-throughput 16S rRNA gene sequencing. The proposed presence of polyphenols in EPE3k was confirmed. EPE3k could significantly decrease the fasting blood glucose and improve fasting glucose tolerance. The hypoglycemic effect of EPE3k was via activation of phosphatidylinositol 3-kinase and suppression of c-Jun N-terminal kinase in liver. EPE3k treatment significantly increased the relative abundance of Akkermansia and decreased the proportion of Alistipes and Turicibacter. The above results indicated that EPE3k could be provided as a new potential therapy for the treatment of type 2 diabetic mellitus. Full article
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18 pages, 3223 KiB  
Article
Screening the Marker Components in Psoralea corylifolia L. with the Aids of Spectrum-Effect Relationship and Component Knock-Out by UPLC-MS2
by Mengjun Shi, Yan Zhang, Miaomiao Song, Yong Sun, Changqin Li and Wenyi Kang
Int. J. Mol. Sci. 2018, 19(11), 3439; https://doi.org/10.3390/ijms19113439 - 2 Nov 2018
Cited by 28 | Viewed by 5381
Abstract
Psoralea corylifolia L., (P. corylifolia), which is used for treating vitiligo in clinic, shows inhibitory and activating effects on tyrosinase, a rate-limiting enzyme of melanogenesis. This study aimed to determine the active ingredients in the ethenal extracts of P. corylifolia on [...] Read more.
Psoralea corylifolia L., (P. corylifolia), which is used for treating vitiligo in clinic, shows inhibitory and activating effects on tyrosinase, a rate-limiting enzyme of melanogenesis. This study aimed to determine the active ingredients in the ethenal extracts of P. corylifolia on tyrosinase activity. The spectrum-effect relationship and knock-out method were established to predict the active compounds. Their structures were then identified with the high resolution mass spectra. A high performance liquid chromatography method was established to obtain the specific chromatograms. Tyrosinase activity in vitro was assayed by the method of oxidation rate of levodopa. Partial least squares method was used to test the spectrum-effect relationships. Chromatographic peaks P2, P4, P9, P10, P11, P13, P21, P26, P28, and P30 were positively related to the activating effects on tyrosinase activity in PE, whereas chromatographic peaks P1, P3, P6, P14, P16, P19, P22, and P29 were negatively related to the activating effects on tyrosinase in the P. corylifolia (PEs). When the sample concentration was 0.5 g·mL−1, equal to the amount of raw medicinal herbs, the target components were daidzein (P2), psoralen (P5), neobavaisoflavone (P13), and psoralidin (P20), which were consistent with the results of spectrum-effect relationships. Full article
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