Molecular Researches in Hypertension
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 650
Special Issue Editor
Special Issue Information
Dear Colleagues,
Identifying causal genes for blood pressure (BP), known as quantitative trait loci (QTLs), allows us to discover the etiology of hypertension pathogenesis well in advance of its underpinning physiology. until now, an increasing number of BP QTLs have been localized in both humans by genome-wide association studies (GWAS) and animal models. Human GWAS have statistically located >900 potential QTLs associated with BP by nucleotide sentinels. They are mostly located in non-coding genome regions and are the results of primate evolution independent of BP control. Future challenges are to qualitatively elevate the outcomes of statistics and the associations of localizing QTLs to establish the physiology and causation of their functions, and to understand the mechanisms of these QTLs determining BP together. Recent molecular breakthroughs have established a principle of one QTL equal to one gene at the level of physiology and in causation. In vivo studies have unified model and human QTLs into a physiological and mechanistic framework that originated from mammalian common ancestors.
Dr. Alan Y. Deng
Guest Editor
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