Molecular Researches in Soft Tissue Sarcomas

Dear Colleagues,

Increasingly, we are looking to develop personalized treatment for cancer patients. Although this approach is becoming more prevalent and advancing therapy for many common cancers, for rare cancers such as sarcomas, this approach, with a few notable exceptions, is particularly problematic. Not only are sarcomas a very heterogeneous group, with over 100 subtypes, but they can also be highly variable in their genetic changes. Whilst some are translocation driven others have highly complex unstable karyotypes. Thus a personalized medicine approach for most sarcoma patients remains challenging and still seems to be far in the future.

In this issue, we look to see how our improved understanding of the genetic, transcriptomic and epigenetic changes of sarcomas can lead to the identification of potential therapeutic windows of opportunity, and enhance a personalized medicine approach. We seek submissions confirming or identifying novel subtype-specific abnormalities based on molecular investigations or profiling that may offer potential as biomarkers, or identification of targets for intervention. We are also interested in studies exploring the effect of targeted interventions, either for sarcomas as a group, or subtype-specific. Exploration of biological actionable traits, such as proliferation migration, invasion, metastasis and the targeting of stem cells with their associated molecular backgrounds in vitro and in vivo are also of interest.

Dr. Karen Sisley
Dr. William R. English
Guest Editors

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• soft tissue sarcomas
• genetic heterogeneity
• stem cells
• molecular interventions
• molecular profilling
• targeted therapy
• personalized medicine
• pharmacogenomics