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Breast Cancer: From Pathophysiology to Novel Therapeutic Approaches

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1753

Special Issue Editor


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Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, 81713108 Bratislava, Slovakia
Interests: cancer biology; cancer cell signalling; flow cytometry; cell culture; cancer immunology; inflammation; apoptosis; immunofluorescence; tumor microenvironment; neurobiology of cancer; survivorship
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Special Issue Information

Dear Colleagues,

Despite the progress in the survival of breast cancer (BrC) patients, there is an urgent need to better understand the mechanisms of cancer progression, recurrence and drug resistance for the development of novel preventive and therapeutic approaches for controlling BrC spread.

This Special Issue is a focused collection of papers on “Breast Cancer: From Pathophysiology to Novel Therapeutic Approaches". It provides an effective way to communicate the current knowledge about the cellular and molecular mechanisms involved in the pathophysiology of BrC and/or suggesting new targets for possible future therapeutical interventions. It is aimed at providing an ample scope for new ideas on how to block or weaken cancer progression to its final stage.

In the current series, we invite papers from basic research, translational research and clinical studies on all aspects of possible targetable mechanisms leading to effective interventions in the future.

Dr. Ľuba Hunáková
Guest Editor

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Keywords

  • cancer progression and metastasis (dissemination, extravasation, angiogenesis, innervation, and metabolic reprogramming)
  • hormonal regulation
  • inflammation
  • drugs
  • exosomes
  • EMT
  • genomic instability and epigenetics
  • apoptosis and toxicity
  • mi-RNA
  • tumor microenvironment
  • stem cells

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Published Papers (1 paper)

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Research

22 pages, 3771 KiB  
Article
How Much Do You Fuse? A Comparison of Cell Fusion Assays in a Breast Cancer Model
by Mareike Sieler, Jessica Dörnen and Thomas Dittmar
Int. J. Mol. Sci. 2024, 25(11), 5668; https://doi.org/10.3390/ijms25115668 - 23 May 2024
Cited by 1 | Viewed by 1351
Abstract
Cell fusion is a biological process that is crucial for the development and homeostasis of different tissues, but it is also pathophysiologically associated with tumor progression and malignancy. The investigation of cell fusion processes is difficult because there is no standardized marker. Many [...] Read more.
Cell fusion is a biological process that is crucial for the development and homeostasis of different tissues, but it is also pathophysiologically associated with tumor progression and malignancy. The investigation of cell fusion processes is difficult because there is no standardized marker. Many studies therefore use different systems to observe and quantify cell fusion in vitro and in vivo. The comparability of the results must be critically questioned, because both the experimental procedure and the assays differ between studies. The comparability of the fluorescence-based fluorescence double reporter (FDR) and dual split protein (DSP) assay was investigated as part of this study, in which general conditions were kept largely constant. In order to be able to induce both a high and a low cell fusion rate, M13SV1 breast epithelial cells were modified with regard to the expression level of the fusogenic protein Syncytin-1 and its receptor ASCT2 and were co-cultivated for 72 h with different breast cancer cell lines. A high number of fused cells was found in co-cultures with Syncytin-1-overexpressing M13SV1 cells, but differences between the assays were also observed. This shows that the quantification of cell fusion events in particular is highly dependent on the assay selected, but the influence of fusogenic proteins can be visualized very well. Full article
(This article belongs to the Special Issue Breast Cancer: From Pathophysiology to Novel Therapeutic Approaches)
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