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The Role of Phytochemicals in Neurological Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 2235

Special Issue Editors


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Guest Editor
Laboratory of Food and Health, Food and Technology Department, National Council for Scientific Research (CEBAS-CSIC), Murcia, Spain
Interests: food and health; bioactive compounds; polyphenols; cell culture and animal models; clinical trials; cardiovascular; cancer; inflammation
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Special Issue Information

Dear Colleagues,

Phytochemicals present in foods, spices and herbs, such as polyphenols, carotenoids and phytosterols, among others, constitute an unlimited source of molecules available for the prevention of numerous diseases and improving human health. Thousands of studies have already firmly established the intimate association between phytochemicals and their significantly neuroprotective activity in neurological disorders (i.e., dementia, cognitive decline, Alzheimer’s, Parkinson’s, stroke, ischemic injury, cancers, etc.), most of which are associated with gradual loss of neurons attributed to increased oxidative stress at the cellular level.

In recent years, bioactive phytochemicals have attracted enormous interest for their roles in preventive strategies (increasing the daily intake) and as adjuvants in the treatment of these pathologies (administered in co-treatment or present in pharmaceutical forms) owing to their potent antioxidant and anti-inflammatory activities. Food supplements containing phytochemicals are now widely used, and it seems that this market will tend to grow more and more in the coming years.

Led by Dr. Alessandro Attanzio, Dr. Antonio Cilla, Dr. Antonio González-Sarrías and our Topical Advisory Panel Member Dr. Ignazio Restivo (University of Palermo). For this Special Issue “The Role of Phytochemicals in Neurological Disorders”, we invite investigators to contribute with original research articles as well as review articles covering the biological effect of natural products in the prevention of neurodegeneration through comparisons between both relevant in vivo and in vitro models and with particular focus on biochemical signaling pathways.

Dr. Alessandro Attanzio
Dr. Antonio Cilla
Dr. Antonio González-Sarrías
Guest Editors

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Keywords

  • phytochemicals
  • neurodegeneration
  • antioxidant activity
  • anti-inflammatory activity
  • nutrition
  • bioactive
  • inhibitor
  • functional foods
  • nutraceuticals
  • molecular mechanism

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Published Papers (1 paper)

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Research

23 pages, 3436 KiB  
Article
Geniposide and Harpagoside Functionalized Cerium Oxide Nanoparticles as a Potential Neuroprotective
by Rosa Martha Pérez Gutiérrez, Luis Miguel Rodríguez-Serrano, José Fidel Laguna-Chimal, Mónica de la Luz Corea, Silvia Patricia Paredes Carrera and Julio Téllez Gomez
Int. J. Mol. Sci. 2024, 25(8), 4262; https://doi.org/10.3390/ijms25084262 - 11 Apr 2024
Viewed by 1423
Abstract
Alzheimer’s disease is associated with protein aggregation, oxidative stress, and the role of acetylcholinesterase in the pathology of the disease. Previous investigations have demonstrated that geniposide and harpagoside protect the brain neurons, and cerium nanoparticles (CeO2 NPs) have potent redox and antioxidant [...] Read more.
Alzheimer’s disease is associated with protein aggregation, oxidative stress, and the role of acetylcholinesterase in the pathology of the disease. Previous investigations have demonstrated that geniposide and harpagoside protect the brain neurons, and cerium nanoparticles (CeO2 NPs) have potent redox and antioxidant properties. Thus, the effect of nanoparticles of Ce NPs and geniposide and harpagoside (GH/CeO2 NPs) on ameliorating AD pathogenesis was established on AlCl3-induced AD in mice and an aggregation proteins test in vitro. Findings of spectroscopy analysis have revealed that GH/CeO2 NPs are highly stable, nano-size, spherical in shape, amorphous nature, and a total encapsulation of GH in cerium. Treatments with CeO2 NPs, GH/CeO2 NPs, and donepezil used as positive control inhibit fibril formation and protein aggregation, protect structural modifications in the BSA-ribose system, have the ability to counteract Tau protein aggregation and amyloid-β1–42 aggregation under fibrillation condition, and are able to inhibit AChE and BuChE. While the GH/CeO2 NPs, treatment in AD induced by AlCl3 inhibited amyloid-β1–42, substantially enhanced the memory, the cognition coordination of movement in part AD pathogenesis may be alleviated through reducing amyloidogenic pathway and AChE and BuChE activities. The findings of this work provide important comprehension of the chemoprotective activities of iridoids combined with nanoparticles. This could be useful in the development of new therapeutic methods for the treatment of neurodegenerative diseases. Full article
(This article belongs to the Special Issue The Role of Phytochemicals in Neurological Disorders)
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