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Phytochemicals and Nutrients in Cancer Prevention and Treatment: Recent Trends and Advances, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 7529

Special Issue Editor


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Guest Editor
Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Sevilla, Spain
Interests: phytochemicals; polyphenols; cancer; antioxidant; pro-oxidant; DNA damage; dietary supplements; signaling pathways; epigenetic; metabolism; immune system
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Special Issue Information

Dear Colleagues,

Although several plant-derived compounds continue to be widely used in cancer therapy (e.g., vinca alkaloids, taxanes, camptothecins, and podophyllotoxin derivatives), most plant species and their phytochemicals have not yet been evaluated as anticancer agents. Plant compounds may also be useful to prevent, delay, or reverse the process of carcinogenesis. However, cancer chemoprevention with plant-derived compounds is an underexplored area of research.

Modifying macronutrient and micronutrient levels through dietary interventions is also a promising strategy not only to prevent cancer but also to improve the survival rates of cancer patients in combination with standard anticancer therapies or even as a stand-alone nutritional therapy.

The aim of this Special Issue is to compile research and review articles assessing the potential of phytochemicals and nutrients in cancer prevention and therapy.

Dr. Estefanía Burgos-Morón
Guest Editor

Manuscript Submission Information

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Keywords

  • phytochemicals
  • polyphenols
  • cancer
  • antioxidant
  • pro-oxidant
  • DNA damage
  • dietary supplements
  • signaling pathways
  • epigenetic
  • metabolism
  • immune system
  • chemoprevention

Published Papers (4 papers)

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Research

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26 pages, 8093 KiB  
Article
Clerodendrum chinense Stem Extract and Nanoparticles: Effects on Proliferation, Colony Formation, Apoptosis Induction, Cell Cycle Arrest, and Mitochondrial Membrane Potential in Human Breast Adenocarcinoma Breast Cancer Cells
by Chuda Chittasupho, Weerasak Samee, Mingkwan Na Takuathung, Siriporn Okonogi, Sathaporn Nimkulrat and Sirivan Athikomkulchai
Int. J. Mol. Sci. 2024, 25(2), 978; https://doi.org/10.3390/ijms25020978 - 12 Jan 2024
Viewed by 1017
Abstract
Breast cancer stands out as the most widespread form of cancer globally. In this study, the anticancer activities of Clerodendrum chinense (C. chinense) stem ethanolic extract were investigated. High-performance liquid chromatography (HPLC) analysis identified verbascoside and isoverbascoside as the major bioactive [...] Read more.
Breast cancer stands out as the most widespread form of cancer globally. In this study, the anticancer activities of Clerodendrum chinense (C. chinense) stem ethanolic extract were investigated. High-performance liquid chromatography (HPLC) analysis identified verbascoside and isoverbascoside as the major bioactive compounds in the C. chinense stem extract. Successfully developed nanoparticles exhibited favorable hydrodynamic diameter, polydispersity index, and surface charge, thus ensuring stability after four months of storage. The total phenolic content and total flavonoid contents in the nanoparticles were reported as 88.62% and 95.26%, respectively. The C. chinense stem extract demonstrated a dose-dependent inhibitory effect on MCF-7, HeLa, A549, and SKOV-3 cancer cell lines, with IC50 values of 109.2, 155.6, 206.9, and 423 µg/mL, respectively. C. chinense extract and NPs exhibited dose-dependent cytotoxicity and the highest selectivity index values against MCF-7 cells. A dose-dependent reduction in the colony formation of MCF-7 cells was observed following treatment with the extract and nanoparticles. The extract induced cytotoxicity in MCF-7 cells through apoptosis and necrosis. C. chinense stem extract and nanoparticles decreased mitochondrial membrane potential (MMP) and induced G0/G1 phase arrest in MCF-7 cells. In conclusion, use of C. chinense stem extract and nanoparticles may serve as a potential therapeutic approach for breast cancer, thus warranting further exploration. Full article
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22 pages, 5468 KiB  
Article
Heterogeneous Cellular Response of Primary and Metastatic Human Gastric Adenocarcinoma Cell Lines to Magnoflorine and Its Additive Interaction with Docetaxel
by Aneta Grabarska, Jarogniew J. Luszczki, Kinga Gawel, Wirginia Kukula-Koch, Małgorzata Juszczak, Adrianna Slawinska-Brych, Grzegorz Adamczuk, Magdalena Dmoszynska-Graniczka, Nataliia Kosheva, Wojciech Rzeski and Andrzej Stepulak
Int. J. Mol. Sci. 2023, 24(21), 15511; https://doi.org/10.3390/ijms242115511 - 24 Oct 2023
Cited by 1 | Viewed by 1018
Abstract
Gastric cancer is the most common cancer and remains the leading cause of cancer death worldwide. In this study, the anticancer action of magnoflorine isolated via counter-current chromatography from the methanolic extract of Berberis vulgaris root against gastric cancer in models of primary [...] Read more.
Gastric cancer is the most common cancer and remains the leading cause of cancer death worldwide. In this study, the anticancer action of magnoflorine isolated via counter-current chromatography from the methanolic extract of Berberis vulgaris root against gastric cancer in models of primary ACC-201 and AGS and metastatic MKN-74 and NCI-N87 cell lines was analyzed. Cell viability and proliferation were tested through the use of MTT and BrdU tests, respectively. Cell cycle progression and apoptosis were evaluated using flow cytometry. The interaction of magnoflorine and docetaxel has been examined through isobolographic analysis. Moreover, potential toxicity was verified in zebrafish in an in vivo model. Gastric cancer cell lines revealed different responses to magnoflorine treatment with regard to viability/proliferation, apoptosis induction and cell cycle inhibition without any undesirable changes in the development of larval zebrafish at the tested concentrations. What is more, magnoflorine in combination with docetaxel produced an additive pharmacological interaction in all studied gastric cancer cell lines, which may suggest a complementary mechanism of action of both compounds. Taken together, these findings provide a foundation for the possibility of magnoflorine as a potential therapeutic approach for gastric cancer and merits further investigation, which may pave the way for clinical uses of magnoflorine. Full article
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20 pages, 3341 KiB  
Article
Metabolomics Analysis Reveals Novel Targets of Chemosensitizing Polyphenols and Omega-3 Polyunsaturated Fatty Acids in Triple Negative Breast Cancer Cells
by Blake R. Rushing, Alleigh Wiggs, Sabrina Molina, Madison Schroder and Susan Sumner
Int. J. Mol. Sci. 2023, 24(5), 4406; https://doi.org/10.3390/ijms24054406 - 23 Feb 2023
Cited by 9 | Viewed by 2574
Abstract
Triple negative breast cancer (TNBC) is a subtype of breast cancer with typically poorer outcomes due to its aggressive clinical behavior and lack of targeted treatment options. Currently, treatment is limited to the administration of high-dose chemotherapeutics, which results in significant toxicities and [...] Read more.
Triple negative breast cancer (TNBC) is a subtype of breast cancer with typically poorer outcomes due to its aggressive clinical behavior and lack of targeted treatment options. Currently, treatment is limited to the administration of high-dose chemotherapeutics, which results in significant toxicities and drug resistance. As such, there is a need to de-escalate chemotherapeutic doses in TNBC while also retaining/improving treatment efficacy. Dietary polyphenols and omega-3 polyunsaturated fatty acids (PUFAs) have been demonstrated to have unique properties in experimental models of TNBC, improving the efficacy of doxorubicin and reversing multi-drug resistance. However, the pleiotropic nature of these compounds has caused their mechanisms to remain elusive, preventing the development of more potent mimetics to take advantage of their properties. Using untargeted metabolomics, we identify a diverse set of metabolites/metabolic pathways that are targeted by these compounds following treatment in MDA-MB-231 cells. Furthermore, we demonstrate that these chemosensitizers do not all target the same metabolic processes, but rather organize into distinct clusters based on similarities among metabolic targets. Common themes in metabolic targets included amino acid metabolism (particularly one-carbon and glutamine metabolism) and alterations in fatty acid oxidation. Moreover, doxorubicin treatment alone generally targeted different metabolites/pathways than chemosensitizers. This information provides novel insights into chemosensitization mechanisms in TNBC. Full article
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Review

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31 pages, 2022 KiB  
Review
Myricetin: A Significant Emphasis on Its Anticancer Potential via the Modulation of Inflammation and Signal Transduction Pathways
by Arshad Husain Rahmani, Ahmad Almatroudi, Khaled S. Allemailem, Wanian M. Alwanian, Basmah F. Alharbi, Faris Alrumaihi, Amjad Ali Khan and Saleh A. Almatroodi
Int. J. Mol. Sci. 2023, 24(11), 9665; https://doi.org/10.3390/ijms24119665 - 2 Jun 2023
Cited by 9 | Viewed by 2239
Abstract
Cancer is a major public health concern worldwide and main burden of the healthcare system. Regrettably, most of the currently used cancer treatment approaches such as targeted therapy, chemotherapy, radiotherapy and surgery usually cause adverse complications including hair loss, bone density loss, vomiting, [...] Read more.
Cancer is a major public health concern worldwide and main burden of the healthcare system. Regrettably, most of the currently used cancer treatment approaches such as targeted therapy, chemotherapy, radiotherapy and surgery usually cause adverse complications including hair loss, bone density loss, vomiting, anemia and other complications. However, to overcome these limitations, there is an urgent need to search for the alternative anticancer drugs with better efficacy as well as less adverse complications. Based on the scientific evidences, it is proven that naturally occurring antioxidants present in medicinal plants or their bioactive compounds might constitute a good therapeutic approach in diseases management including cancer. In this regard, myricetin, a polyhydroxy flavonol found in a several types of plants and its role in diseases management as anti-oxidant, anti-inflammatory and hepato-protective has been documented. Moreover, its role in cancer prevention has been noticed through modulation of angiogenesis, inflammation, cell cycle arrest and induction of apoptosis. Furthermore, myricetin plays a significant role in cancer prevention through the inhibition of inflammatory markers such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (Cox-2). Moreover, myricetin increases the chemotherapeutic potential of other anticancer drugs through modulation of cell signaling molecules activity. This review elaborates the information of myricetin role in cancer management through modulating of various cell-signaling molecules based on in vivo and in vitro studies. In addition, synergistic effect with currently used anticancer drugs and approaches to improve bioavailability are described. The evidences collected in this review will help different researchers to comprehend the information about its safety aspects, effective dose for different cancers and implication in clinical trials. Moreover, different challenges need to be focused on engineering different nanoformulations of myricetin to overcome the poor bioavailability, loading capacity, targeted delivery and premature release of this compound. Furthermore, some more derivatives of myricetin need to be synthesized to check their anticancer potential. Full article
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