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Latest Treatment Strategy for Neurological Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 8744

Special Issue Editor


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Guest Editor
1. Fondazione Policlinico Universitario A.Gemelli, IRCCS, 00168 Rome, Italy
2. Department of Neurosciences, Università Cattolica del S. Cuore, 00168 Rome, Italy
Interests: neurogenetics; neurological diseases; neurodegeneration; clinical neurophysiology; neuromuscular disorders
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Special Issue Information

Dear Colleagues,

To date, there are few effective treatments approved and available for patients with neurological disorders, and in many cases, the therapeutic options focus on the symptomatic management of disease manifestations, aiming to improve patients' quality of life.

In recent years, basic researchers and clinicians have worked together, sharing research projects and planning clinical trials, to improve this scenario, with results leading in some cases to a real therapeutic revolution, such as in spinal muscular atrophy (SMA). Important therapeutic advantages have also been achieved in other rare neurological pathologies both of genetic and autoimmune etiology, such as hereditary transthyretin amyloidosis (ATTRv) or myasthenia gravis. At the same time, innovative approaches have changed the therapeutic options for common neurological diseases, such as migraine.

Finally, an increasingly accurate metabolic–molecular characterization of hereditary and acquired neurological disorders (e.g., mitochondrial diseases, multiple sclerosis, neurodegenerative diseases of the central nervous system and movement disorders) is defining new therapeutic perspectives, sometimes unexpected.

For this Special Issue titled “Latest Treatment Strategy for Neurological Disorders”, we are looking for original research articles and state-of-the-art reviews on preclinical and clinical therapeutic approaches, both in common and rare neurological diseases, focused on a molecular point of view.

Dr. Guido Primiano
Guest Editor

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Keywords

  • personalized medicine
  • neurological disorders
  • neurogenetic diseases
  • mitochondrial diseases
  • spinal muscular atrophy
  • neurodegenerative diseases
  • autoimmune disease
  • treatment
  • therapeutics
  • biological mechanisms

Published Papers (1 paper)

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Review

31 pages, 1762 KiB  
Review
Vitamin D in Neurological Diseases
by Domenico Plantone, Guido Primiano, Carlo Manco, Sara Locci, Serenella Servidei and Nicola De Stefano
Int. J. Mol. Sci. 2023, 24(1), 87; https://doi.org/10.3390/ijms24010087 - 21 Dec 2022
Cited by 16 | Viewed by 8186
Abstract
Vitamin D may have multiple effects on the nervous system and its deficiency can represent a possible risk factor for the development of many neurological diseases. Recent studies are also trying to clarify the different effects of vitamin D supplementation over the course [...] Read more.
Vitamin D may have multiple effects on the nervous system and its deficiency can represent a possible risk factor for the development of many neurological diseases. Recent studies are also trying to clarify the different effects of vitamin D supplementation over the course of progressive neurological diseases. In this narrative review, we summarise vitamin D chemistry, metabolism, mechanisms of action, and the recommended daily intake. The role of vitamin D on gene transcription and the immune response is also reviewed. Finally, we discuss the scientific evidence that links low 25-hydroxyvitamin D concentrations to the onset and progression of severe neurological diseases, such as multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, migraine, diabetic neuropathy and amyotrophic lateral sclerosis. Completed and ongoing clinical trials on vitamin D supplementation in neurological diseases are listed. Full article
(This article belongs to the Special Issue Latest Treatment Strategy for Neurological Disorders)
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