Innovations in Neuropharmacology for Neurodegenerative Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 560
Special Issue Editor
Interests: pharmacological treatment of mood; anxiety; psychotic disorders
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Special Issue Information
Dear Colleagues,
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, represent some of the most significant challenges currently facing modern medicine. These conditions are typified by progressive neuronal loss, frequently accompanied by debilitating cognitive, motor, and behavioral symptoms, which have a markedly deleterious impact on the quality of life of patients. Despite extensive research, effective treatments remain elusive, underscoring the urgent need for innovative neuropharmacological strategies.
The Special Issue, entitled "Innovations in Neuropharmacology for Neurodegenerative Diseases", aims to examine the latest advances and conceptual shifts in the treatment and comprehension of these intricate disorders. This collection aims to provide a comprehensive platform for the latest developments in drug discovery, molecular mechanisms, and translational approaches that address both the symptoms and underlying pathophysiology of neurodegeneration.
The following areas will be given particular attention, although this list is not exhaustive:
- Novel Therapeutics: The development of small molecules, biologics, gene therapies, and personalized medicine approaches targeting neurodegenerative pathways represents a significant area of research.
- Mechanistic Insights: The objective is to elucidate the molecular and cellular mechanisms underlying neuronal death, including oxidative stress, mitochondrial dysfunction, protein aggregation, neuroinflammation, and impaired autophagy.
- Biomarkers and Diagnostics: The development of novel biomarkers for the early diagnosis, disease progression, and therapeutic monitoring of various diseases.
- Drug Delivery Systems: Advances in nanotechnology, strategies for enhancing blood-brain barrier permeability, and other novel drug delivery methods.
- Repurposing and Polypharmacy: An investigation into the potential of existing pharmaceuticals for the treatment of neurodegenerative disorders, coupled with the formulation of innovative combination therapies.
This theme is aligned with current trends and challenges in the field of molecular sciences, with a particular emphasis on the integration of systems biology, bioinformatics, and high-throughput screening in the context of neuropharmacology. As research increasingly focuses on the personalization of therapy and disease-modifying strategies, this issue also seeks to address unmet clinical needs and bridge the gap between basic science and clinical application.
We welcome contributions from a range of perspectives, including experimental studies, clinical trials, meta-analyses, and reviews. Submissions employing innovative methodologies, such as omics technologies, organoids, and artificial intelligence-driven drug discovery, are strongly encouraged. Integrated approaches that draw upon insights from multiple disciplines, including pharmacology, neuroscience, molecular biology, and computational sciences, are strongly encouraged.
It is our intention that this Special Issue will serve to stimulate dialogue and collaboration among researchers, clinicians, and industry leaders, thereby facilitating the advancement of the field towards the development of more effective treatments for neurodegenerative diseases.
Prof. Dr. Andrea Fagiolini
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- neurodegenerative diseases
- neuropharmacology
- alzheimer's disease
- parkinson's disease
- gene therapy
- drug delivery systems
- molecular mechanisms
- biomarkers in neurodegeneration
- neuroinflammation
- personalized medicine
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