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Gels
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Biobased Gels for Drugs and Cells (2nd Edition)
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Biobased Gels for Drugs and Cells (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Processing and Engineering".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 596

Special Issue Editors

Dr. Resmi Anand

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Guest Editor
Nanotechnologies Unit, Luxembourg Institute of Science and Technology, Esch Sur Alzette L-4362, Luxembourg
Interests: biomaterials; hydrogels; nanoparticles; microparticles; drug delivery; growth factor delivery; tissue engineering; bioprinting; antimicrobial coatings
Special Issues, Collections and Topics in MDPI journals
Dr. David Duday

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Guest Editor
Nanotechnologies Unit, Luxembourg Institute of Science and Technology, Esch Sur Alzette L-4362, Luxembourg
Interests: biomaterials; sustainable materials; antimicrobial coatings; delivery systems; hydrogels; nanoparticles; microparticles; formulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biobased gels are materials made from renewable biological resources, including plants, microbes, and organic debris. These gels are distinguished by their capacity to absorb water and swell, resulting in a hydrophilic network that may encapsulate a variety of molecules. Biobased gels have gained popularity due to their sustainability and potential uses in a variety of sectors, including biomedicine. They offer significant advantages, including ease of availability, biodegradability, low toxicity, and enhanced sustainability. Furthermore, these gels create an ideal environment for cell growth, making them particularly suitable for biomedical applications.

This Special Issue of Gels invites contributions exploring the synthesis, chemical modification, and characterization of biobased gels, cell–biobased hydrogel interactions, and various applications of biobased gels, particularly their potential in drug delivery and cell-related applications. We invite researchers to submit original research articles, perspectives, case studies, reviews, and critical reviews that highlight the use of biobased gels in drug delivery and cell-based therapies.

Dr. Resmi Anand
Dr. David Duday
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biobased gel
  • drug delivery
  • cell encapsulation
  • biomaterials
  • cell–biomaterial interactions
  • chitosan
  • gelatin
  • alginate
  • lignin
  • cellulose

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Related Special Issue

Published Papers (1 paper)

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Research

19 pages, 3586 KB  
Article
Exploratory Multivariate Analysis of Mediator Organization in Canine Platelet-Rich Gel Under NSAID Exposure
by Jorge U. Carmona, Julián Ospina and Catalina López
Gels 2026, 12(3), 246; https://doi.org/10.3390/gels12030246 - 14 Mar 2026
Viewed by 368
Abstract
Platelet-rich gel (PRG) is a fibrin-based biobased biomaterial generated by activating platelet-rich plasma (PRP), yet its biological characterization has commonly relied on univariate measurements of isolated mediators. This study aimed to define the multivariate biological organization of PRG and related hemocomponents (PRP, chemically [...] Read more.
Platelet-rich gel (PRG) is a fibrin-based biobased biomaterial generated by activating platelet-rich plasma (PRP), yet its biological characterization has commonly relied on univariate measurements of isolated mediators. This study aimed to define the multivariate biological organization of PRG and related hemocomponents (PRP, chemically induced platelet lysate (CIPL), and plasma) in a canine model under single exposure to non-steroidal anti-inflammatory drugs (NSAIDs). In a randomized crossover design (n = 6 dogs), hemocomponents were produced at baseline (0 h) and 6 h after administration of carprofen or firocoxib. Platelet and white blood cell (WBC) counts, growth factors (platelet-derived growth factor-BB (PDGF-BB) and transforming growth factor beta-1 (TGF-β1)), and cytokines (tumor necrosis factor alpha (TNF-α), interleukin-1 beta, and interleukin-10) were integrated using linear mixed-effects modeling, principal component analysis (PCA), and hierarchical clustering. PRG was derived from a leukocyte-poor PRP precursor with moderate platelet enrichment (~1.6-fold vs. whole blood) and a marked WBC reduction (~8–9-fold). In mixed-effects modeling, hemocomponent type significantly influenced the PDGF-BB:TNF-α log-ratio, with PRG (estimate −1.12; 95% CI −1.34 to −0.90) and plasma (−2.06; 95% CI −2.28 to −1.84) lower than PRP, while CIPL did not differ. Time and NSAID effects were not supported. PCA identified two orthogonal axes explaining 61.3% of total variance (PC1 = 43.7%, PC2 = 18.6%), separating a platelet/trophic dimension (log(PDGF-BB), log(TGF-β1), platelet count, PDGF-BB:TNF-α log-ratio) from an inflammatory dimension (log(TNF-α), log(IL-1β)). Overall, hemocomponent composition emerged as the primary determinant of mediator organization, supporting the interpretation of PRG as a structured, biomaterial defined by coordinated mediator networks. Full article
(This article belongs to the Special Issue Biobased Gels for Drugs and Cells (2nd Edition))
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