Food Bioactive Compounds in Chronic Diseases Prevention and Ageing

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 661

Special Issue Editors


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Guest Editor
Department of Nutritional Science and Dietetics, Faculty of Health Sciences, University of Peloponnese, New Building, Antikalamos, 24100 Kalamata, Greece
Interests: biochemical analysis; bioactive compounds analysis; metabolomics; proteomics; senescence; chronic diseases; cancer

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Guest Editor
Department of Nutritional Science and Dietetics, Faculty of Health Sciences, University of Peloponnese, New Building, Antikalamos, 24100 Kalamata, Greece
Interests: bioactive components; phytochemicals; PAF-inhibitors; Mediterranean diet; cardiovascular disease; cancer; sarcopenia; body composition
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Special Issue Information

Dear Colleagues,

In the face of rising chronic disease prevalence and the biological complexities of ageing, the scientific community is increasingly focusing on the preventive potential of diet-derived bioactive compounds. These naturally occurring molecules—from polyphenols and flavonoids to carotenoids, phytosterols, and bioactive peptides—have shown compelling evidence of modulating key cellular and molecular pathways involved in oxidative stress, inflammation, metabolic regulation, and cellular ageing.

With this Special Issue, entitled “Food Bioactive Compounds in Chronic Diseases Prevention and Ageing”, we aim to understand the mechanistic and clinical aspects of specific dietary components by integrating data from molecular nutrition, biochemistry, and clinical studies. We warmly invite the submission of original research articles, reviews, and short communications that delve into the molecular mechanisms, health impacts, and translational potential of food bioactives.

We look forward to receiving your valuable contributions that will collectively enhance our understanding of how nutritional science can be harnessed to promote healthier ageing and reduce the global burden of chronic diseases.

Dr. Sotirios-Spyridon Vamvakas
Dr. Paraskevi Detopoulou
Guest Editors

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Keywords

  • phytochemicals
  • antioxidants
  • mediterranean diet
  • chronic diseases
  • senescence
  • sarcopenia
  • body composition
  • molecular nutrition
  • clinical studies
  • biochemical analysis

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Published Papers (1 paper)

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Research

12 pages, 935 KiB  
Article
The Performance of Pleurotus eryngii β-Glucans on Protein Digestion and the Release of Free Amino Acids in the Bloodstream of Obese Adults
by Charalampia Amerikanou, Stamatia-Angeliki Kleftaki, Aristea Gioxari, Dimitra Tagkouli, Alexandra Kasoura, Stamatia Simati, Chara Tzavara, Alexander Kokkinos, Nick Kalogeropoulos and Andriana C. Kaliora
Foods 2025, 14(15), 2649; https://doi.org/10.3390/foods14152649 - 28 Jul 2025
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Abstract
Pleurotus eryngii is an edible mushroom with previously characterized β-glucans. Its potential to ameliorate postprandial glycemia and regulate appetite at the postprandial state has been previously shown. However, its effect on protein digestion remains unexplored. We aimed to investigate the effect of baked [...] Read more.
Pleurotus eryngii is an edible mushroom with previously characterized β-glucans. Its potential to ameliorate postprandial glycemia and regulate appetite at the postprandial state has been previously shown. However, its effect on protein digestion remains unexplored. We aimed to investigate the effect of baked P. eryngii with a known β-glucan content (4.5 g) on plasma free amino acids of patients with central obesity and metabolic abnormalities at a postprandial state. In this acute, randomized controlled cross-over study, thirteen healthy male volunteers consumed one meal that was prepared with P. eryngii and one control meal; each meal was separated by one month. Blood was collected, and plasma was isolated at different timepoints before and after the consumption. Gas chromatography–mass spectrometry was used to quantify 24 free amino acids in the plasma samples. The area under the curve with respect to increase (AUCi) was computed, and the AUCi for aromatic amino acids was found to be higher after the consumption of the control meal compared to the P. eryngii meal (p = 0.027 for phenylalanine, p = 0.008 for tyrosine, and p = 0.003 for tryptophan). The above novel findings suggest that the β-glucans present in P. eryngii mushrooms are potential modulators of AA release into the bloodstream. Full article
(This article belongs to the Special Issue Food Bioactive Compounds in Chronic Diseases Prevention and Ageing)
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