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Bioactive Compounds in Food: Analysis and Human Health
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Bioactive Compounds in Food: Analysis and Human Health

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 11848

Special Issue Editors

Dr. Paraskevi Detopoulou

E-Mail Website
Guest Editor
Head of Clinical Nutrition Department, General Hospital Korgialenio Benakio, Athens, Greece
Interests: clinical nutrition; bioactive compounds; lipids; cardiovascular disease
Dr. Haralabos Christos Karantonis

E-Mail Website
Guest Editor
Laboratory of Food Chemistry, Biochemistry and Technology, Department of Food Science and Nutrition, University of the Aegean, 81440 Myrina, Greece
Interests: analysis of food microconstituents; mechanisms of oxidation, thrombosis, and inflammation; health effects of bioactive food microconstituents on chronic inflammatory diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive compounds in foods are usually minor constituents with health effects. They may belong to several categories with differentiated structures such as polyphenols, carotenoids, organosulfur compounds, terpenoids, fatty acids, platelet activating factor (PAF) antagonists, immune-boosting substances, probiotics, prebiotics and others. Nanoparticles being used in the food industry may enhance product features and can also be listed as bioactive compounds. In vitro, animal and human studies have pointed to several health effects of these compounds, such as antioxidant, anti-inflammatory, and anti-thrombotic effects, which in turn render these bioactive compounds as potentially cardioprotective, immune-boosting, anti-diabetic and anti-cancer agents. In the COVID-19 era, such food constituents may contribute to combating infection and possibly affect the clinical course of the disease.

This Special Issue aims to attract original research and review articles describing current findings on the effects of bioactive compounds.

Potential topics include (but are not limited to) the following:

  • Characterization and analysis of bioactive compounds;
  • Potential mechanisms of action of bioactive compounds;
  • Bioactive compounds and oxidative stress;
  • Bioactive compounds and thrombosis;
  • Bioactive compounds and inflammation;
  • Bioactive compounds and cancer;
  • Bioactive compounds and cardiovascular disease;
  • Bioactive compounds and diabetes;
  • Bioactive compounds and hypertension;
  • Bioactive compounds and obesity;
  • Bioactive compounds and COVID-19;
  • Effects of bioactive compounds in ICU;
  • Immune-boosting properties of bioactive compounds;
  • Nanoparticles and health effects;
  • PAF antagonists in foods.

Dr. Paraskevi Detopoulou
Dr. Haralabos Christos Karantonis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive peptides
  • polyphenols
  • food carotenoids
  • non-nutrients
  • probiotics
  • prebiotics
  • disease
  • nanoparticles

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

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22 pages, 1659 KiB  
Article
Exploring the Effect of Resveratrol, Tyrosol, and Their Derivatives on Platelet-Activating Factor Biosynthesis in U937 Cells
by Filio Petsini, Maria Detopoulou, Maria Choleva, Ioannis K. Kostakis, Elizabeth Fragopoulou and Smaragdi Antonopoulou
Molecules 2024, 29(22), 5419; https://doi.org/10.3390/molecules29225419 - 17 Nov 2024
Viewed by 1012
Abstract
Platelet-activating factor (PAF) is a potent lipid mediator, involved in thrombosis, inflammation, and atherosclerosis. The protective effect of wine and olive oil against atherosclerotic diseases is largely attributed to their phenolic compounds and mostly to resveratrol and tyrosol. Both compounds have been reported [...] Read more.
Platelet-activating factor (PAF) is a potent lipid mediator, involved in thrombosis, inflammation, and atherosclerosis. The protective effect of wine and olive oil against atherosclerotic diseases is largely attributed to their phenolic compounds and mostly to resveratrol and tyrosol. Both compounds have been reported to inhibit PAF biosynthesis in interleukin-1β (IL-1β)-stimulated monocytes and also to attenuate PAF biosynthesis in cell lysates. The aim of this study was to investigate the effects of resveratrol, tyrosol, and their derivatives on unstimulated U937 cells and to explore the intracellular messaging pathways that participate in the activation of PAF biosynthesis in the same cell line. Tyrosol and its derivatives did not exert any substantial effect on PAF biosynthesis. Resveratrol (50 and 100 μM), as well as its methoxy derivative (5–20 μM), caused a reduction in the PAF biosynthetic enzymes’ activity by 20–43% after 24 h of incubation. On the other hand, lower resveratrol concentration (10 μM) and higher concentration of the methoxy derivative (50 μM) increased the Ca2+-dependent lyso–PAF acetyltransferase (LysoPAF-ATC) activity by 28–45% after half-hour incubation via p38 mitogen-activated protein kinase (p38-MAPK) action. IL-1β activated PAF biosynthetic pathways via different signaling pathways, with phospholipase C-β (PLC-β) being a key enzyme. Full article
(This article belongs to the Special Issue Bioactive Compounds in Food: Analysis and Human Health)
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Review

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35 pages, 1248 KiB  
Review
A Comprehensive Review on Polyphenols of White Wine: Impact on Wine Quality and Potential Health Benefits
by Ina Ćorković, Anita Pichler, Josip Šimunović and Mirela Kopjar
Molecules 2024, 29(21), 5074; https://doi.org/10.3390/molecules29215074 - 26 Oct 2024
Cited by 1 | Viewed by 1404
Abstract
Polyphenols are associated with various beneficial health effects. These compounds are present in edible plants such as fruits and vegetables, and the human body absorbs them through the consumption of foods and beverages. Wine is recognized as a rich source of these valuable [...] Read more.
Polyphenols are associated with various beneficial health effects. These compounds are present in edible plants such as fruits and vegetables, and the human body absorbs them through the consumption of foods and beverages. Wine is recognized as a rich source of these valuable compounds, and it has been well established that polyphenols present in red wine possess numerous biologically active functions related to health promotion. Therefore, most scientific research has been focused on red wine polyphenols, whereas white wine polyphenols have been neglected. This review presents the summarized information about the most abundant polyphenols in white wines, their concentration, their impact on wine quality and their potential health effects, such as neuroprotective and cardioprotective activities, antioxidant potential, antimicrobial activity and their positive effects on lipids. These findings are an effort to help compensate for the relative lack of relevant data in the scientific literature regarding white wine polyphenols. Full article
(This article belongs to the Special Issue Bioactive Compounds in Food: Analysis and Human Health)
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17 pages, 1237 KiB  
Review
Weight Loss Supplements
by Irene Dini and Andrea Mancusi
Molecules 2023, 28(14), 5357; https://doi.org/10.3390/molecules28145357 - 12 Jul 2023
Cited by 7 | Viewed by 8608
Abstract
Being overweight or obese can predispose people to chronic diseases and metabolic disorders such as cardiovascular illnesses, diabetes, Alzheimer’s disease, and cancer, which are costly public health problems and leading causes of mortality worldwide. Many people hope to solve this problem by using [...] Read more.
Being overweight or obese can predispose people to chronic diseases and metabolic disorders such as cardiovascular illnesses, diabetes, Alzheimer’s disease, and cancer, which are costly public health problems and leading causes of mortality worldwide. Many people hope to solve this problem by using food supplements, as they can be self-prescribed, contain molecules of natural origin considered to be incapable of causing damage to health, and the only sacrifice they require is economic. The market offers supplements containing food plant-derived molecules (e.g., primary and secondary metabolites, vitamins, and fibers), microbes (probiotics), and microbial-derived fractions (postbiotics). They can control lipid and carbohydrate metabolism, reduce appetite (interacting with the central nervous system) and adipogenesis, influence intestinal microbiota activity, and increase energy expenditure. Unfortunately, the copious choice of products and different legislation on food supplements worldwide can confuse consumers. This review summarizes the activity and toxicity of dietary supplements for weight control to clarify their potentiality and adverse reactions. A lack of research regarding commercially available supplements has been noted. Supplements containing postbiotic moieties are of particular interest. They are easier to store and transport and are safe even for people with a deficient immune system. Full article
(This article belongs to the Special Issue Bioactive Compounds in Food: Analysis and Human Health)
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